The accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen causes ER stress response, activates the unfolded protein response (UPR) signal pathway and consequently induces the expression of ER-located molecular chaperones (such as BiP, calnexin, etc.
真核细胞内质网中未折叠蛋白的积累会引起内质网胁迫(ER stress),激活未折叠蛋白应答(UPR)信号途径,从而诱导内质网中分子伴侣的表达(比如BiP和Calnexin等)。
To explore the possible mechanisms of cell damage resulted from cholesterol overloading in hepatocyte, the cell apoptosis, the unfolded protein response (UPR) and the correlation between them were tested in cholesterol-overloading human normal hepatic cell line L02.
资料显示肝细胞胆固醇聚积可导致细胞损伤，为了探讨胆固醇负荷时肝细胞损伤作用及可能机制，我们体外检测了在胆固醇负荷条件下肝细胞的凋亡发生，未折叠蛋白应答活化，以及它们间的相关性。
An improved pruned-enriched-rosenbluth method for protein folding;
求解蛋白质折叠问题的改进PERM算法
Improved population migration algorithm for prediction of protein folding;
一种改进人口迁移算法在蛋白质折叠模拟中的应用
Method of quantum gravity on protein folding;
蛋白质折叠的量子引力理论
Results cDNA microarray analysis demonstrated that there exists unfolded protein response in AsGnT-V7721 ce.
方法用WesternBlot验证GnTⅤ的反义cDNA稳转的细胞株AsGnTⅤ7721(AsGnTⅤSMMC7721)中GnTⅤ表达,用基因芯片技术比较AsGnTⅤ7721与7721(SMMC7721)细胞的基因表达差异,同时用RTPCR和WesternBlot检测AsGnTⅤ7721细胞中未折叠蛋白质反应信号通路关键分子Bip和XBP1的表达变化。
Cholesterol Overloading Leads to Hepatic L02 Cell Damage Through Activation of the Unfolded Protein Response
肝细胞高胆固醇负荷活化未折叠蛋白应答介导细胞凋亡损伤的研究
The Role of Unfolded Protein Response in Cataract Pathogenesis;
未折叠蛋白反应在白内障发病机制中作用的实验研究
The Study on Cholesterol Induced Unfolded Protein Response and ACAT2 Expression;
胆固醇诱导的未折叠蛋白反应及其调节acat2基因表达的探讨
The Expression and Significance of the Correlation Factor of Unfolded Protein Response: XBP1、Bip and VEGF-C in Hepatocarcinoma;
未折叠蛋白反应相关因子XBP1、Bip、VEGF-C在肝癌中的表达和意义的研究
Experimental Study on Effects of Targeted Agents on Unfolded Protein Response in Multiple Myeloma Cells;
靶向治疗药物对骨髓瘤细胞未折叠蛋白反应影响的实验研究
Unfolded protein response involves in acute renal ischemia/reperfusion injury in mice
未折叠蛋白反应参与小鼠急性肾缺血/再灌注损伤
chaperone protein
伴侣蛋白质[可与新生、未折叠、错折叠或聚合的多肽相结合]
Regulation of Cholesterol Transport-related Proteins Expressions by Oleic Acid-induced Endoplasmic Reticulum Stress in CaCo-2 Cells
油酸通过未折叠蛋白反应调节肠粘膜上皮细胞胆固醇转运相关蛋白的表达
Protein Pucker Simulation Based on Grid Computation Environment
基于网格计算环境的蛋白质折叠模拟应用
Electron microscopic localization of IRE1 on the retinal ganglion cells and oligodendrocytes on retinal nerve of the rat after optic nerve crushing
视神经损伤后发生非折叠蛋白反应的超微证据
Unfolded Protein Response and Endoplasmic Reticulum Stress in Hereditary Inclusion Body Myopathy;
遗传性包涵体肌病非折叠蛋白反应及内质网应激蛋白表达分析
A Novel Ensemble Classifier and Its Application in Protein Fold Recognition;
一种高效集成分类器及其在蛋白质折叠识别中的应用研究
The Application of Distributed Parallel Processing and Complex Network in Protein Folding;
分布式并行处理与复杂网络在蛋白质折叠中的应用
Unfolded Protein Responses of the Retinal Ganglion Cells after Optical Nerve Crash in Rats;
大鼠视神经夹伤后视网膜节细胞的非折叠蛋白反应
A Research on Evidences on the Development of Unfolded Protein Responses in Optical Nerve after Its Injury
视神经损伤后视神经发生非折叠蛋白反应的超微证据研究
Inhibition of Proteasome to Disrupt Unfolded Protein Response and Autophagy in Multiple Myeloma Cells
抑制蛋白酶体干扰骨髓瘤细胞未折迭蛋白反应与自噬
This becomes our prediction for the fold of that protein.
这也就是我们对该蛋白质折叠的预测。
The garbage in question is abnormally folded proteins.
问题出就出在这些异常折叠的蛋白质。