Objective: To study the effects of genistein on the expression of urokinase-type plasminogen activator (uPA) and the activity of protein tyrosine kinase (PTK) in MDA-MB-453 cells, and explore the molecular mechanism of anti-angiogenesis in HER-2/neu-overexpressing breast cancer by genistein.
目的: 观察染料木黄酮(亦称三羟异黄酮,genistein,Gen)对MDA-MB-453乳腺癌细胞尿激酶型纤维蛋白溶酶原激活剂(urokinase-type plasminogen activator,uPA)表达及蛋白酪氨酸激酶(protein tyrosine kinase,PTK)活性的影响,探讨Gen抗HER-2/neu高表达乳腺癌血管生成的分子机制。
Objective To explore the inhibitory effect of genistein on oncogene HER-2/neu-overexpressing breast cancer xenograft tumors and its relationship with urokinase type plasminogen activator (uPA) expression.
目的 探讨三羟异黄酮(genistein)对原癌基因HER 2 neu高表达乳腺癌异种移植瘤的抑制作用及其与尿激酶型纤维蛋白溶酶原激活剂(urokinasetypeplasminogenactivator ,uPA)表达变化的关系。
The results of theoretical analysis indicate that ILLLIT surely can enhance the activity of plasminogen activator,which is advantageous to decreasing the aggregate degree of erythrocyte.
理论分析结果表明 ,ILLLIT提高了纤维蛋白溶酶原激活素的活性 ,有利于红细胞聚集指数的下
The results of theoretical analysis indicate that ILLLIT surely can enhance the activity of plasminogen activator, which is advantageous to decreasing the aggregate degree of erythrocyte.
理论分析表明 IL L LIT提高了纤维蛋白溶酶原激活素的活性 ,有利于红细胞聚集指数的下降。
The thrombolytic effect of reteplase in treating rabbit retinal vein occlusion
组织型纤维蛋白溶解酶原激活剂缺失突变体治疗兔视网膜静脉阻塞的疗效
Construction of Tissue Plasminogen Activator-annexin A5 Fusion Gene
组织型纤溶酶原激活剂—膜联蛋白A5融合基因的构建
Expressions of Survivin and uPA in human cerebral gliomas
脑胶质瘤组织中Survivin和尿激酶型纤溶酶原激活物蛋白的表达
Experimental Study on Posterior Vitreous Detachment Induced by Tissue Plasminogen Activator Combined with Hyaluronidase in Rabbits;
组织纤维蛋白溶酶原激活剂联合透明质酸酶致玻璃体后脱离的动物实验研究
Comparison of Recombinant Tissue Plasminogen Activator, Urokinase and Defibrase in Vitro Simulation of Thrombolytic Test
重组织型纤溶酶原激活剂、尿激酶和降纤酶体外溶栓效果比较
Role of Tissue-Type Plasminogen Activator in Neonatal Rat with Hypoxia-Ischemia Brain Damage
组织纤维蛋白溶酶原激活剂在新生大鼠缺氧缺血性脑损伤中的作用
Clinical Study of the Expression of Tissue Factor and Urokinase Plasminogen Activator Receptor in Breast Cancer
组织因子、尿激酶型纤溶酶原激活剂受体在乳腺癌中的表达
Evaluation of the therapeutic effect of thrombolytic therapy with rt-PA and nursing intervention in patients with acute myocardial infarction
急性心肌梗死重组组织型纤溶酶原激活剂溶栓治疗的观察及护理
Therapeutic effect observation of thrombolysis with rt-PA intravenous in recurrent cerebral infarction
重组组织型纤溶酶原激活剂对再发性脑梗死静脉溶栓治疗评价
Therapeutic Effect of Ultra Earlier Thrombolysis of Recombinant Tissue Plasminogen Activator in Acute Cerebral Infarction
重组组织型纤溶酶原激活剂超早期溶栓治疗急性脑梗死的疗效
Thrombolytic therapy with intravenous recombinant tissue plasminogen activator for acute cerebral infarction
重组组织型纤溶酶原激活剂静脉溶栓治疗急性脑梗死19例
Study on Recombinant Nonglycosylated Urokinase-type Plasminogen Activator;
重组非糖基化尿激酶型纤溶酶原激活剂的研究
The Effect of Astragalus and Safflower Mixture on Expression of Plasminogen Activator Inhibitor 1 in Renal Tubulointerstitial Fibrosis in Rats with Unilateral Ureteral Obstruction;
芪红合剂对肾间质纤维化模型大鼠肾组织中纤溶酶原激活物抑制物-1表达的影响
The Recombinant Human Tissue-type Plasminogen Activator in the Treatment of Deep Venous Thrombosis of the Lower Extremities
重组组织型纤溶酶原激活剂治疗下肢深静脉血栓形成的临床应用
Experimental study on prevention of the peritoneal adhesion by recombinant tissue-type plasminogen activator on rats
重组组织型纤溶酶原激活剂预防大鼠腹腔粘连的实验研究
Therapeutic effect evaluation of recombinant tissue plasminogen activator in hyper acute cerebral infarction
重组组织型纤溶酶原激活剂治疗急性脑梗死的疗效评价
Construction of Tissue-type Plasminogen Activator Variants and Their Expression in Prokaryotic and Eukaryotic Cells;
组织型纤溶酶原激活剂（t-PA）突变体的构建及其表达研究
Construction of Eukaryotic Expessing Vector of Tissue Plasminogen Activator (t-PA);
组织型纤溶酶原激活剂（t-PA）真核表达载体的构建