aneuploidy

1. Aneuploidy is associated with cancer.: 非整倍体与肿瘤相关。

2. One measure of malignancy is aneuploidy by flow cytometry.: 恶性肿瘤的检测方法之一是通过流式细胞计显示异倍性。

3. Aneuploidy in human population is a serious genetic problem.: 在人类群体中非整倍性是个严重的遗传问题。

4. Amniocentesis is the standard prenatal detection procedure for aneuploidy.: 羊膜穿刺术是出生前检测非整倍体的金标准。

5. Ultrasound can frequently detect many abnormalities in fetuses with aneuploidy.: 超声波通常可检测出多数异常的胎儿染色体。

6. The worse the neoplasm, the greater the degree of aneuploidy and the worse the prognosis.: 肿瘤越恶性，异倍性程度越大，报告结果就越差。

7. The aneuploidy and SPF index are also the important factors which can influent the prognosis.: 异倍体的出现以及SPF值是影响预后的重要因素。

8. For the past several years, scientists have used mice to study the genetic causes of aneuploidy.: 在过去几年中，科学家利用小鼠研究了非整倍体的遗传原因。

9. The researchers hope that, in the future, they can develop what they are calling "aneuploidy therapy.": 研究人员希望将来他们能够研究出他们称之为“非整倍体疗法”的药物。

10. Chromosomal mutation, called aneuploidy, is the cause instead, and it destabilizes chromosomal patterns.: 非整倍的染色体突变才是真正的诱因，因为它破坏了染色体的类型。

11. Results The difference of DNA aneuploidy style between benign and malignant tumor cells was significant.: 结果甲状腺恶性肿瘤细胞与良性肿瘤细胞DNA倍体类型有非常显著的差异。

12. Objective To study the relationship between DNA aneuploidy and biological behavior of thyroid tumor cells.: 目的探讨甲状腺肿瘤细胞DNA倍体类型与肿瘤生物学特性的关系及预后意义。

13. They saw that patients whose tumours had high levels of aneuploidy didn't live for as long after treatment.: 他们发现具有高水平非整倍体的肿瘤患者在治疗后没有活多久。

14. Overexpression of STK15 induces increased Numbers of centrosome, aneuploidy, and transformation of the cells.: STK15过表达诱导中心体数目增多，异倍体形成和细胞转化。

15. Researches have shown that flow cytometric DNA analysis can detect DNA aneuploidy in as much as 92% of tumors.: 研究显示，流式细胞术DNA倍体分析可以在92 %的实体肿瘤上检测到DNA异倍体的存在。

16. Despite its high incidence and severe clinical consequences, very little is known about how aneuploidy originates in human.: 尽管非整倍体的发生率高、临床后果严重，但人类对于非整倍体究竟是如何发生的仍然不清楚。

17. The distribution of DNA ploidy was 2.47 ~ 11.79c, with no normal diploid (2c). All the 41 cases were aneuploidy and polyploid.: 结果表明，DNA倍体水平分布范围为2.47 ~ 1.79，无正常二倍体(2c)，41例皆为非正倍体的异多倍体。

18. And, notes Hughes, finding aneuploidy in one or two cells of an embryo does not always mean that the embryo will not be viable.: 而且如Hughes指出的，从一个胚胎中发现1到2个非整倍性的细胞并不意味着胚胎就无法存活。

19. Objective: To establish the method of aneuploidy detection in human oocytes by multicolor fluorescence in-situ hybridization (M-FISH).: 目的建立多色荧光原位杂交技术检测人卵细胞染色体非整倍体的方法。

20. Purpose To study the feasibility of PRINS for rapid prenatal diagnosis of fetal 18 aneuploidy in metaphase cells from umbilical blood.: 目的探讨引物原位标记法（PRINS）结合经腹脐血穿刺，应用于脐血中期细胞快速产前诊断18号染色体数目异常的可行性。

21. Results 64% of oocytes were normal, 36% of oocytes were aneuploidy, of which 22% were due to nondisjunction and 14% unbalanced prepision.: 结果64%的卵细胞核型正常，36%的卵细胞为非整倍体，其中22%为同源染色体不分离，14%为姐妹染色单体非平衡性过早分离。

22. Once an abnormal growth is defined as a cancer, or neoplasm, high cellular aneuploidy is also considered by some to be a sign of aggressiveness.: 一旦某个异常增生给归类为癌症或肿瘤，也有人将其中细胞的高度非整倍体性，视为癌细胞侵犯性的征兆。

23. Objective To analyse the clinical significance of the immunophenotype, aneuploidy and cell circle distribution in children with acute leukemia (al).: 目的分析小儿急性白血病(AL)的免疫表型、异倍体、细胞周期分布状况的临床意义。

24. The result suggested that TBZ may induce aneuploidy by the pathway of tubulin polymerization inhibition which is able to lead to chromosomal malsegregation.: 研究表明，TBZ可能通过抑制微管蛋白聚合来影响染色体正常分离，诱发非整倍体。

25. To ensure genome integrity and prevent aneuploidy, eukaryotes have evolved an integrated protective mechanism, including cell cycle control, checkpoint control, and DNA repair.: 真核生物对维持基因组的稳定性及防止非整倍体的产生，有其一套完整的保护机制，即细胞周期调控、检验点调控以及对损伤DNA的修复。

26. Results During long term cultivation, the population doubling time of the cells became shorter and the percentage of aneuploidy chromosomes and colonies grown in soft AGAR increased.: 结果卵圆细胞在培养过程中倍增时间逐渐缩短，非整倍体染色体数目增加，在软琼脂中生长的克隆增多。

27. The new study suggests that errors in the quantity of DNA and how it's packaged inside cancer cells - called aneuploidy - might affect the immune system's ability to destroy the cells.: 这个新研究表明，DNA数量的错误和它在癌细胞里面如何包装-叫做非整倍体-可能影响免疫系统的能力来毁坏肿瘤细胞。

28. Conclusion: Metastases of tumors would cause presence of DNA aneuploidy cells and increases of apoptosis rate and SPF in peripheral blood monocytes of the patients with malignant tumors.: 结论：肿瘤转移能引起患者外周血细胞中出现DNA异倍体，并使血细胞凋亡水平和增殖活性上调。

29. Aneuploidy is an important point at issue in human reproductive biology, accounting for both a major proportion of miscarriages and various congenital malformation syndromes among newborns.: 非整倍体是人类生殖生物学中的重要问题，是引起自发性流产和新生儿中多种先天性畸形综合征的主要原因。

30. Objective to access the probability of detecting DNA aneuploidy in exfoliated airway epithelia cells of sputum specimens with the automated imaging cytometry for the diagnosis of lung cancer.: 目的探讨全自动图像细胞仪对痰液脱落细胞DNA异倍体的检测在肺癌诊断中的价值。

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