2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,(4S,4aR,5S,5aR,12aS)-
- 中文别名：甲烯土霉素
- 中文释义：甲烯土霉素;美他环素
- 英文别名：methacycline;
Germicilclin;
Adriamicina;
gs-2876;
6-methylene-oxytetracyclin;
METHACYCLINE;
Globociclina;
6-methyleneoxytetracycline;
rondomycin;
metacycline;
bialatan;
methacyclineamphoteric;
Cyclobiotic;
12aalpha))-ph
- CAS No.：914-00-1
- 分子式：C22H22N2O8
- 分子量：442.42
- 精确分子量：442.13800
- PSA：181.62000
- InChI：InChI=1/C22H22N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-6,10,14-15,17,25-27,31-32H,1,23H2,2-3H3/b21-13+/t10-,14-,15+,17+,22+/m1/s1
- 分子结构式：
物化性质
- 密度：
- 1.66g/cm3
- 沸点：
- 695.1ºC at 760mmHg
- 闪点：
- 374.2ºC
- 折射率：
- 1.753
安全信息
- 密度：
- 1.66g/cm3
- 沸点：
- 695.1ºC at 760mmHg
- 闪点：
- 374.2ºC
- 折射率：
- 1.753
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QI9275000
- CHEMICAL NAME :
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-
- CAS REGISTRY NUMBER :
- 914-00-1
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C22-H22-N2-O8
- MOLECULAR WEIGHT :
- 442.46
- WISWESSER LINE NOTATION :
- L E6 C666 BV FV MY CU GU LHTT&&J DQ EQ GVZ HQ IN1&1 KQ MU1 RQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 660 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 3750 ug/L
- REFERENCE :
- BCPHBM British Journal of Clinical Pharmacology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1974- Volume(issue)/page/year: 16,127,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1538 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1150 (estimated) No. of Female Employees: 591 (estimated)
