trimethylcolchicinic acid
- 中文别名：三甲基秋水仙素酸
- 中文释义：三甲基秋水仙素酸
- 英文别名：N-Deacetyl Colchiceine;
TRIMETHYLCOLCHICINIC ACID
- CAS No.：3482-37-9
- 分子式：
C19H21NO5
- 分子量：343.37
- 精确分子量：343.14200
- PSA：91.01000
- InChI：The Key: IRVWPZRYDQROLU-ZDUSSCGKSA-N
- 分子结构式：
物化性质
- 密度：
- 1.32g/cm3
- 熔点：
- >230ºC (dec.)
- 沸点：
- 629ºC at 760mmHg
- 闪点：
- 334.2ºC
- 折射率：
- 1.628
安全信息
- 密度：
- 1.32g/cm3
- 熔点：
- >230ºC (dec.)
- 沸点：
- 629ºC at 760mmHg
- 闪点：
- 334.2ºC
- 折射率：
- 1.628
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0960000
- CHEMICAL NAME :
- Colchicinic acid, trimethyl-
- CAS REGISTRY NUMBER :
- 3482-37-9
- BEILSTEIN REFERENCE NO. :
- 3008992
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C19-H21-N-O5
- MOLECULAR WEIGHT :
- 343.41
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JZ NQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 23 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Blood - hemorrhage
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- REFERENCE :
- CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950
