5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-12-ol,6,7,7a,8-tetrahydro-11-methoxy-7-methyl-, (7aS)-
- 中文别名：空褐麟碱
- 中文释义：空褐麟碱;球紫堇碱
- 英文别名：bulbocapnine;
10-Methoxy-6-methyl-1,2-methylendioxy-aporphan-11-ol;
4-Hydroxy-3-methoxy-5,6-methylenedioxy-aporphin;
Bulbocapnine;
Bulbokaprin
- CAS No.：298-45-3
- 分子式：
C19H19NO4
- 分子量：325.36
- 精确分子量：325.13100
- PSA：51.16000
- InChI：The Key: LODGIKWNLDQZBM-LBPRGKRZSA-N
- 分子结构式：
物化性质
- 密度：
- 1.342g/cm3
- 熔点：
- 199-200ºC
- 沸点：
- 504ºC at 760mmHg
- 闪点：
- 258.6ºC
- 折射率：
- 1.653
- 蒸汽压：
- 8.84E-11mmHg at 25°C
安全信息
- 密度：
- 1.342g/cm3
- 熔点：
- 199-200ºC
- 沸点：
- 504ºC at 760mmHg
- 闪点：
- 258.6ºC
- 折射率：
- 1.653
- 蒸汽压：
- 8.84E-11mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CE1050000
- CHEMICAL NAME :
- 6a-alpha-Aporphin-11-ol, 10-methoxy-1,2-(methylenedioxy)-
- CAS REGISTRY NUMBER :
- 298-45-3
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C19-H19-N-O4
- MOLECULAR WEIGHT :
- 325.39
- WISWESSER LINE NOTATION :
- T D56 J666 1A T EO GO RN FH&&&TTJ KQ LO1 R1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 145 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 155,69,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 195 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 56,85,1936
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 79 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#12068
