4(3H)-Quinazolinone,3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-
- 中文别名：常山乙素
- 中文释义：常山乙素;3-[3-[(2R,3S)-3-羟基-2-哌啶基]-2-氧代丙基]-4(3H)-喹唑啉酮;Β-常山碱
- 英文别名：Febrifugine;
febrifungine
- CAS No.：24159-07-7
- 分子式：C16H19N3O3
- 分子量：301.34000
- 精确分子量：301.14300
- PSA：84.22000
- InChI：The Key: FWVHWDSCPKXMDB-CABCVRRESA-N
- 分子结构式：
物化性质
- 密度：
- 1.39 g/cm3
- 沸点：
- 508.2ºC at 760 mmHg
- 闪点：
- 261.1ºC
- 折射率：
- 1.673
- 蒸汽压：
- 3.76E-11mmHg at 25°C
安全信息
- 密度：
- 1.39 g/cm3
- 沸点：
- 508.2ºC at 760 mmHg
- 闪点：
- 261.1ºC
- 折射率：
- 1.673
- 蒸汽压：
- 3.76E-11mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VA3450000
- CHEMICAL NAME :
- 4(3H)-Quinazolinone, 3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, (2S-trans)-
- CAS REGISTRY NUMBER :
- 24159-07-7
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C16-H19-N3-O3
- MOLECULAR WEIGHT :
- 301.38
- WISWESSER LINE NOTATION :
- T66 BVN ENJ C1V1- BT6NTJ CQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 71,1048,1949
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,867,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 161,400,1948
海关数据
中国海关编码：2933990090
- 概述：
- 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
