flumethasone

物化性质

密度：

1.36 g/cm3

熔点：

237-240ºC

沸点：

569.8ºC at 760 mmHg

闪点：

298.4ºC

折射率：

1.579

蒸汽压：

2.33E-15mmHg at 25°C

安全信息

密度：

1.36 g/cm3

熔点：

237-240ºC

沸点：

569.8ºC at 760 mmHg

闪点：

298.4ºC

折射率：

1.579

蒸汽压：

2.33E-15mmHg at 25°C

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TU3832000

CHEMICAL NAME :

Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha- methyl-

CAS REGISTRY NUMBER :

2135-17-3

LAST UPDATED :

199612

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C22-H28-F2-O5

MOLECULAR WEIGHT :

410.50

WISWESSER LINE NOTATION :

L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1 FQ G1 LF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

DOSE :

20 ug/kg

SEX/DURATION :

female 38 week(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - parturition

REFERENCE :

JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 28,407,1972

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

DOSE :

30 ug/kg

SEX/DURATION :

female 31 week(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - abortion

REFERENCE :

JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 160,867,1972

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

DOSE :

20 ug/kg

SEX/DURATION :

female 40 week(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - parturition

REFERENCE :

THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 20,267,1983

分子结构与计算化学数据

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:3

3.氢键受体数量:7

4.可旋转化学键数量:2

5.互变异构体数量:3

6.拓扑分子极性表面积:94.8

7.重原子数量:29

8.表面电荷:0

9.复杂度:839

10.同位素原子数量:0

11.确定原子立构中心数量:9

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1