19-Norpregn-4-en-20-yne-3,17-diol,3,17-diacetate, (3b,17a)-
- 中文别名：双醋炔诺醇
- 中文释义：双醋炔诺醇;Cyclopentadecane;BRN 0111811;JM 1498;NSC 180811;1,4,8,11-tetraazoniacyclotetradecane;1,4,8,11-Tetraazacyclotetradecane;CROWN ETHER/12-CROWN-4;12-Crown-4;三乙基二胺;1,4-二氮杂二环[2.2.2]辛烷;benzoxazol;benzoxazole;Phenoxathrin;Phenoxthin;USAF DO-17;Dibenzoo
- 英文别名：ethynodiol diacetate;
Femulen;
ETHYNODIOL DIACETATE;
Metrodiol diacetate;
[(3S,8R,9S,10R,13S,14S,17R)-17-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;
Luto-metrodiol;
Ethynodiol diacetate;
3β,17β-Diacetoxy-17α-ethynyl-4-estrene;
Ovulen 50;
Ethinodiol diacetate;
17a-Ethynyl-4-estren-3b,17-diol diacetate;
Ovulen;
Cervicundin;
Continuin;
Metrodiol
- CAS No.：297-76-7
- 分子式：
C24H32O4
- 分子量：384.51
- 精确分子量：384.23000
- PSA：52.60000
- InChI：InChI=1/C24H32O4/c1-5-16-13-22-21-8-6-17-12-18(27-14(2)25)7-9-19(17)20(21)10-11-24(22,4)23(16)28-15(3)26/h1,12,16,18-23H,6-11,13H2,2-4H3/t16-,18+,19?,20?,21?,22?,23+,24+/m1/s1
- 分子结构式：
物化性质
- 密度：
- 1.14 g/cm3
- 熔点：
- 128 - 131ºC
- 沸点：
- 461.1ºC at 760 mmHg
- 闪点：
- 221.8ºC
- 折射率：
- 1.544
- 蒸汽压：
- 8.11E-09mmHg at 25°C
安全信息
- 密度：
- 1.14 g/cm3
- 熔点：
- 128 - 131ºC
- 沸点：
- 461.1ºC at 760 mmHg
- 闪点：
- 221.8ºC
- 折射率：
- 1.544
- 蒸汽压：
- 8.11E-09mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RC8963000
- CHEMICAL NAME :
- 19-Nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol diacetate
- CAS REGISTRY NUMBER :
- 297-76-7
- LAST UPDATED :
- 199510
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C24-H32-O4
- MOLECULAR WEIGHT :
- 384.56
- WISWESSER LINE NOTATION :
- L E5 B666 MUTJ E1 FOV1 F1UU1 OOV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 840 ug/kg
- SEX/DURATION :
- female 21 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 840 ug/kg
- SEX/DURATION :
- female 24 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 700 ug/kg
- SEX/DURATION :
- female 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 6 mg/kg
- SEX/DURATION :
- male 30 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- DOSE :
- 240 mg/kg
- SEX/DURATION :
- male 30 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 16500 ug/kg
- SEX/DURATION :
- male 60 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 48 mg/kg
- SEX/DURATION :
- male 12 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1400 ug/kg
- SEX/DURATION :
- female 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 140 mg/kg
- SEX/DURATION :
- female 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 120 ug/kg
- SEX/DURATION :
- female 3 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1560 ug/kg
- SEX/DURATION :
- female 1-3 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 5 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Mammal - cattle Cells - not otherwise specified
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 120,390,1974 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 21,387,1979
