phosgene

物化性质

外观与性状：

无色气体

密度：

0.94 g/mL at 20 °C

熔点：

-118ºC

沸点：

8.2ºC at 760 mmHg

闪点：

4 °C

折射率：

1.419

存储条件/存储方法：

库房通风低温干燥,轻装轻卸

稳定性相关：

1.稳定性^[18] 稳定

2.禁配物^[19] 水、醇类、碱类

3.避免接触的条件^[20] 潮湿空气、受热

4.聚合危害^[21] 不聚合

其它信息：

1.性状：纯品为无色有特殊气味的气体，低温时为黄绿色液体。^[1]

2.熔点（ºC）：-127.9~-118^[2]

3.沸点（ºC）：8.2^[3]

4.相对密度（水=1）：1.4^[4]

5.相对蒸气密度（空气=1）：3.4^[5]

6.饱和蒸气压（kPa）：161.6（20ºC）^[6]

7.临界温度（ºC）：182^[7]

8.临界压力（MPa）：5.67^[8]

9.辛醇/水分配系数：-0.710^[9]

10.溶解性：微溶于水，溶于芳烃、苯、四氯化碳、氯仿、乙酸等多数有机溶剂。^[10]

11.液相标准热熔(J·mol^-1·K^-1)：112.0

12.气相标准声称热(焓)( kJ·mol^-1) ：-219.1

13.气相标准熵(J·mol^-1·K^-1) ：283.87

14.气相标准生成自由能( kJ·mol^-1)：-208.4

15.气相标准热熔(J·mol^-1·K^-1)：57.70

安全信息

外观与性状：

无色气体

密度：

0.94 g/mL at 20 °C

熔点：

-118ºC

沸点：

8.2ºC at 760 mmHg

闪点：

4 °C

折射率：

1.419

存储条件/存储方法：

库房通风低温干燥,轻装轻卸

稳定性相关：

1.稳定性^[18] 稳定

2.禁配物^[19] 水、醇类、碱类

3.避免接触的条件^[20] 潮湿空气、受热

4.聚合危害^[21] 不聚合

其它信息：

1.性状：纯品为无色有特殊气味的气体，低温时为黄绿色液体。^[1]

2.熔点（ºC）：-127.9~-118^[2]

3.沸点（ºC）：8.2^[3]

4.相对密度（水=1）：1.4^[4]

5.相对蒸气密度（空气=1）：3.4^[5]

6.饱和蒸气压（kPa）：161.6（20ºC）^[6]

7.临界温度（ºC）：182^[7]

8.临界压力（MPa）：5.67^[8]

9.辛醇/水分配系数：-0.710^[9]

10.溶解性：微溶于水，溶于芳烃、苯、四氯化碳、氯仿、乙酸等多数有机溶剂。^[10]

11.液相标准热熔(J·mol^-1·K^-1)：112.0

12.气相标准声称热(焓)( kJ·mol^-1) ：-219.1

13.气相标准熵(J·mol^-1·K^-1) ：283.87

14.气相标准生成自由能( kJ·mol^-1)：-208.4

15.气相标准热熔(J·mol^-1·K^-1)：57.70

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SY5600000

CHEMICAL NAME :

Phosgene

CAS REGISTRY NUMBER :

75-44-5

BEILSTEIN REFERENCE NO. :

1098367

LAST UPDATED :

199801

DATA ITEMS CITED :

39

MOLECULAR FORMULA :

C-Cl2-O

MOLECULAR WEIGHT :

98.91

WISWESSER LINE NOTATION :

GVG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

50 ppm/5M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63. Discontinued. Volume(issue)/page/year: 3,231,1933

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

360 mg/m3/30M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,99,1982

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

25 ppm/30M

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes

REFERENCE :

29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968 Volume(issue)/page/year: -,207,1968

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

190 mg/m3/15M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,99,1982

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

50 ppm/5M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 138,65,1928

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

11 mg/m3/30M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63. Discontinued. Volume(issue)/page/year: 3,231,1933 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

200 ppb/6H/4W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - changes in lung weight

REFERENCE :

FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 37,54,1997

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

250 ppb/4H/17D-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - changes in lung weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

REFERENCE :

JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 19,413,1986

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

500 ppb/6H/12W-I

REFERENCE :

FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 37,54,1997 *** REVIEWS *** ACGIH TLV-TWA 0.40 mg/m3 (0.1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 35,165,1975 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 28,272,1974 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.1 ppm (0.4 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,208,1971 OSHA PEL (Gen Indu):8H TWA 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 0.1 ppm (0.5 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.05 ppm (0.2 mg/m3) JAN 1993 OEL-FINLAND:STEL 0.05 ppm (0.2 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.1 ppm (0.1 mg/m3) JAN 1993 OEL-SWEDEN:TWA 0.05 ppm (0.2 mg/m3) JAN 1993 OEL-THAILAND:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-TURKEY:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHOSGENE-air:10H TWA 0.1 ppm;CL 0.2 ppm/15MREFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 57710 No. of Facilities: 408 (estimated) No. of Industries: 10 No. of Occupations: 11 No. of Employees: 5729 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 57710 No. of Facilities: 57 (estimated) No. of Industries: 5 No. of Occupations: 10 No. of Employees: 2358 (estimated) No. of Female Employees: 282 (estimated)

毒理学数据：

1.急性毒性^[11] LC50：1400mg/m³（大鼠吸入，1/2h）

2.刺激性 暂无资料

3.亚急性与慢性毒性^[12] 动物吸入0.0008mg/L，每天5h，共5d，40%出现肺水肿。

4.其他^[13]

LCLo：50ppm（人吸入，5min），360mg/m³（人吸入30min）

TCLo：25ppm（人吸入，30min）

生态数据：

1.生态毒性^[14] LD50：60mg/L（24h）（鱼）

2.生物降解性^[15]

好氧生物降解（h）：168~672

厌氧生物降解（h）：678~2688

3.非生物降解性^[16]

光解最大光吸收波长范围（nm）：234.2~274.5

一级水解半衰期（h）：1.9

4.其他有害作用^[17] 该物质对环境有危害，应特别注意对空气、水环境及水源的污染。

MSDS

第一部分：化学品名称

分子结构与计算化学数据

分子结构数据

1、摩尔折射率：16.4

2、摩尔体积（cm³/mol）：64.9

3、等张比容（90.2K）：153.8

4、表面张力（dyne/cm）：31.5

5、介电常数：无可用

6、偶极距（10^-24cm³）：无可用

7、极化率：6.5

计算化学数据

1.疏水参数计算参考值（XlogP）:1.8

2.氢键供体数量:0

3.氢键受体数量:1

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积17.1

7.重原子数量:4

8.表面电荷:0

9.复杂度:29

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1