isothebaine
- 中文别名：異蒂巴因
- 中文释义：異蒂巴因;異副嗎啡
- 英文别名：isothebaine;
ISOTHEBAINE;
2,11-dimethoxy-1-hydroxyaporphine
- CAS No.：568-21-8
- 分子式：
C19H21NO3
- 分子量：311.37500
- 精确分子量：311.15200
- PSA：41.93000
- InChI：The Key: RQCOQZNIQLKGTN-ZDUSSCGKSA-N
- 分子结构式：
物化性质
- 密度：
- 1.219g/cm3
- 沸点：
- 489.2ºC at 760mmHg
- 闪点：
- 249.6ºC
- 折射率：
- 1.617
安全信息
- 密度：
- 1.219g/cm3
- 沸点：
- 489.2ºC at 760mmHg
- 闪点：
- 249.6ºC
- 折射率：
- 1.617
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CE1017000
- CHEMICAL NAME :
- 6a-alpha-Aporphin-1-ol, 2,11-dimethoxy-
- CAS REGISTRY NUMBER :
- 568-21-8
- BEILSTEIN REFERENCE NO. :
- 0039931
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C19-H21-N-O3
- MOLECULAR WEIGHT :
- 311.41
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),14,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 26 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- AUPMAF Acta Universitatis Palackianae Olomucensis, Facultatis Medicae. (Statni Pedagogicke Nakladatelstvi, Ostrovni 30, 1 Nove Mesto, 113 01 Prague 1, Czechoslovakia) V.24- 1961- Volume(issue)/page/year: 61,213,1972
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),14,1946
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),14,1946
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