phenazocine

物化性质

密度：

1.097g/cm3

沸点：

461ºC at 760mmHg

闪点：

220.5ºC

折射率：

1.59

蒸汽压：

4.05E-09mmHg at 25°C

安全信息

密度：

1.097g/cm3

沸点：

461ºC at 760mmHg

闪点：

220.5ºC

折射率：

1.59

蒸汽压：

4.05E-09mmHg at 25°C

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

PB8890000

CHEMICAL NAME :

2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-phenethyl-

CAS REGISTRY NUMBER :

127-35-5

LAST UPDATED :

199012

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C22-H27-N-O

MOLECULAR WEIGHT :

321.50

WISWESSER LINE NOTATION :

T C666 A KN&TTJ A1 B1 EQ K2R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

SPECIES OBSERVED :

Human

DOSE/DURATION :

29 ug/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :

NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901- Volume(issue)/page/year: 61,83,1961

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

90 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 1,1,1981

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

56 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,309,1970

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

20 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02061

分子结构与计算化学数据

分子结构数据

1、 摩尔折射率：98.89

2、 摩尔体积（cm³/mol）：293.0

3、 等张比容（90.2K）：751.1

4、 表面张力（dyne/cm）：43.1

5、 极化率（10-24cm3）：39.20