sodium dichromate

物化性质

外观与性状：

一种红色或红色-橙色结晶固体

密度：

1.267 g/mL at 25 °C(lit.)

熔点：

356.7ºC

沸点：

250-251 °C(lit.)

闪点：

>230 °F

折射率：

n20/D 1.4850(lit.)

存储条件/存储方法：

库房通风低温干燥,轻装轻卸,与有机物、还原剂、硫、磷易燃物,食品原料分开存放

稳定性相关：

1.有毒！长期吸入含六价铬的有毒产品，能破坏鼻黏膜，引起鼻黏膜和鼻中隔软骨穿孔，使呼吸器官受到损伤。皮肤接触重铬酸钠溶液和粉末时易引起铬疮和皮炎，甚至失明。因此，如有重铬酸钠溶液或粉末溅到皮肤上，应立即用大量水冲洗干净；如不慎溅入眼睛内，应立即用大量水冲洗15min以上，并滴入鱼肝油和30%磺胺乙酰溶液进行处理。误食铬盐会引起急性铬中毒，出现腹痛、呕吐、便血，严重者会出现血尿、抽搐、精神失常，应立即用亚硫酸钠溶液洗胃解毒，口服1%的氧化镁稀溶液，喝牛奶和蛋清等。

2.稳定性^[11] 稳定

3.禁配物^[12] 强还原剂、醇类、水、活性金属粉末、硫、磷、强酸

4.避免接触的条件^[13] 潮湿空气

5.聚合危害^[14] 不聚合

其它信息：

1.性状：橘红色结晶，易潮解。^[1]

2.熔点（℃）：357（无水）^[2]

3.沸点（℃）：400（分解）^[]3

4.相对密度（水=1）：2.52^[4]

5.溶解性：溶于水，不溶于醇。^[5]

安全信息

外观与性状：

一种红色或红色-橙色结晶固体

密度：

1.267 g/mL at 25 °C(lit.)

熔点：

356.7ºC

沸点：

250-251 °C(lit.)

闪点：

>230 °F

折射率：

n20/D 1.4850(lit.)

存储条件/存储方法：

库房通风低温干燥,轻装轻卸,与有机物、还原剂、硫、磷易燃物,食品原料分开存放

稳定性相关：

1.有毒！长期吸入含六价铬的有毒产品，能破坏鼻黏膜，引起鼻黏膜和鼻中隔软骨穿孔，使呼吸器官受到损伤。皮肤接触重铬酸钠溶液和粉末时易引起铬疮和皮炎，甚至失明。因此，如有重铬酸钠溶液或粉末溅到皮肤上，应立即用大量水冲洗干净；如不慎溅入眼睛内，应立即用大量水冲洗15min以上，并滴入鱼肝油和30%磺胺乙酰溶液进行处理。误食铬盐会引起急性铬中毒，出现腹痛、呕吐、便血，严重者会出现血尿、抽搐、精神失常，应立即用亚硫酸钠溶液洗胃解毒，口服1%的氧化镁稀溶液，喝牛奶和蛋清等。

2.稳定性^[11] 稳定

3.禁配物^[12] 强还原剂、醇类、水、活性金属粉末、硫、磷、强酸

4.避免接触的条件^[13] 潮湿空气

5.聚合危害^[14] 不聚合

其它信息：

1.性状：橘红色结晶，易潮解。^[1]

2.熔点（℃）：357（无水）^[2]

3.沸点（℃）：400（分解）^[]3

4.相对密度（水=1）：2.52^[4]

5.溶解性：溶于水，不溶于醇。^[5]

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

HX7700000

CHEMICAL NAME :

Dichromic acid, disodium salt

CAS REGISTRY NUMBER :

10588-01-9

LAST UPDATED :

199806

DATA ITEMS CITED :

52

MOLECULAR FORMULA :

Cr2-O7.2Na

MOLECULAR WEIGHT :

261.98

WISWESSER LINE NOTATION :

NA2 CR2-O7

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

250 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - cough Gastrointestinal - nausea or vomiting Skin and Appendages - sweating

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Liver - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

80 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

26200 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

18400 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

335 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

335 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

23 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Amphibian - frog

DOSE/DURATION :

196 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

7280 mg/kg/2Y-C

TOXIC EFFECTS :

Cardiac - changes in coronary arteries

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - pig

DOSE/DURATION :

3438 ug/kg/39W-C

TOXIC EFFECTS :

Cardiac - other changes

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

252 ug/m3/78W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intrapleural

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

160 mg/kg/69W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

20 mg/kg

SEX/DURATION :

male 8 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male Endocrine - androgenic

TYPE OF TEST :

DNA damage

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Rodent - hamster Ovary

REFERENCE :

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 17,219,1980 *** REVIEWS *** ACGIH TLV-TWA 0.05 mg(Cr)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Confirmed human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 49,49,1990 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,205,1980 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 49,49,1990 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 2,100,1973 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,205,1980 IARC Cancer Review:Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 49,49,1990 TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 9,105,1971 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Cr,22,1974 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.5 mg(Cr)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,35,1971 OSHA PEL (Gen Indu):CL 0.1 mg(CrO3)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 0.1 mg(CrO3)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 0.1 mg(CrO3)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 0.1 mg(CrO3)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHROMIUM(VI)-air:10H CA TWA 0.001 mg(Cr)/m3REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0073 No. of Facilities: 7838 (estimated) No. of Industries: 85 No. of Occupations: 64 No. of Employees: 44269 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0073 No. of Facilities: 11523 (estimated) No. of Industries: 118 No. of Occupations: 82 No. of Employees: 136313 (estimated) No. of Female Employees: 24542 (estimated)

毒理学数据：

1.急性毒性^[6] LD50：50mg/kg（大鼠经口）

2.刺激性 暂无资料

3.致突变性^[7] 微生物致突变：鼠伤寒沙门菌50μg/皿。DNA损伤：大鼠肝10μmol/L。姐妹染色单体交换：仓鼠肺140μg/L。

4.致癌性^[8] IARC致癌性评论：组1，对人类是致癌物。

5.其他^[9] 大鼠腹腔注射最低中毒剂量（TDLo）：20mg/kg（染毒8周，雄性），影响精子生成。

生态数据：

1.生态毒性^[10]

LC50：18~133mg/L（96h）（鱼）

IC50：0.58mg/L（72h）（藻类）

2.生物降解性 暂无资料

3.非生物降解性 暂无资料

MSDS

Name:	Sodium dichromate Material Safety Data Sheet
Synonym:	Sodium bichromate
CAS:	10588-01-9

Section 1 - Chemical Product   MSDS Name:Sodium dichromate Material Safety Data Sheet
Synonym:Sodium bichromate
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
10588-01-9	Sodium dichromate	100	234-190-3

Hazard Symbols: T+ O N
Risk Phrases: 21 25 26 37/38 41 43 46 8 49 50/53
Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Harmful in contact with skin. Toxic if swallowed. Very toxic by inhalation. Irritating to respiratory system and skin. Risk of serious damage to eyes. May cause sensitization by skin contact. May cause heritable genetic damage. Contact with combustible material may cause fire. May cause cancer by inhalation. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns.
Skin:
Causes skin irritation. Harmful if absorbed through the skin. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Chrome ulcers, penetrating lesions of the skin, occur chiefly on the hand and forearm where there has been a break in the epidermis.
Ingestion:
Harmful if swallowed. Causes gastrointestinal tract burns. May cause liver and kidney damage.
Inhalation:
May be fatal if inhaled. Causes respiratory tract irritation. May cause ulceration and perforation of the nasal septum if inhaled in excessive quantities.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Prolonged or repeated exposure may lead to asthma and perforation of the nasal septum. May cause cancer in humans.
Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do NOT induce vomiting. Get medical aid immediately.
If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person.
Inhalation:
POISON material. If inhaled, get medical aid immediately. Remove victim to fresh air. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Strong oxidizer. Contact with other material may cause fire. Substance is noncombustible.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Do not flush into a sewer. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Isolate area and deny entry. Provide ventilation. Keep combustibles (wood, paper, oil, etc.,) away from spilled material.
Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Avoid contact with clothing and other combustible materials. Do not breathe dust. Use only with adequate ventilation or respiratory protection.
Storage:
Do not store near combustible materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from reducing agents. Avoid storage on wood floors.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear a chemical apron. Wear appropriate clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystals
Color: orange to red
Odor: odorless
pH: 4 (10% solution)
Vapor Pressure: 0 mm Hg @ 20 deg C
Viscosity: Not available.
Boiling Point: 400 deg C (dec)
Freezing/Melting Point: 357 deg C
Autoignition Temperature: Not available.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 400 deg C
Solubility in water: Freely Soluble.
Specific Gravity/Density: 2.52 @ 13C
Molecular Formula: Na2Cr2O7
Molecular Weight: 261.97
Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Reducing agents, anhydrides, finely powdered metals, hydrazine, hydroxylamine, sulfuric acid, organic matter, hydrochloric acid, hydrazine derivatives, combustible materials.
Hazardous Decomposition Products:
No data available.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 10588-01-9: HX7700000 HX7720000 LD50/LC50:
CAS# 10588-01-9: Oral, rat: LD50 = 50 mg/kg.
LC50 (inhalation, rat): 0.124 mg/l/4H.
mg/kg.
Carcinogenicity:
Sodium dichromate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
  Other No information available.
Section 13 - DISPOSAL CONSIDERATIONS
  Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: Oxidizing Solid, Toxic, N.O.S.
Hazard Class: 5.1
UN Number: 3087
Packing Group: III
IMO
Shipping Name: Oxidizing Solid, Toxic, N.O.S.
Hazard Class: 5.1
UN Number: 3087
Packing Group: III
RID/ADR
Shipping Name: Oxidizing Solid, Toxic, N.O.S.
Hazard Class: 5.1
UN Number: 3087
Packing group: III
USA RQ:CAS# 10588-01-9: 10 lb final RQ; 4.54 kg final RQ
Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ O N
Risk Phrases:
R 46 May cause heritable genetic damage.
R 49 May cause cancer by inhalation.
R 21 Harmful in contact with skin.
R 25 Toxic if swallowed.
R 26 Very toxic by inhalation.
R 37/38 Irritating to respiratory system and skin.
R 41 Risk of serious damage to eyes.
R 43 May cause sensitization by skin contact.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
R 8 Contact with combustible material may cause
fire.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 10588-01-9: 3
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
CAS# 10588-01-9 is listed on Canada's DSL List.
CAS# 10588-01-9 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 10588-01-9 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

分子结构与计算化学数据

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:7

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积124

7.重原子数量:11

8.表面电荷:0

9.复杂度:194

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:3