acrolein

物化性质

外观与性状：

无色至略黄色液体

密度：

0.839 g/mL at 25 °C(lit.)

熔点：

−87 °C(lit.)

沸点：

53 °C(lit.)

闪点：

−2 °F

水溶解性：

Soluble. 21.25 g/100 mL

折射率：

n20/D 1.403(lit.)

蒸汽压：

261mmHg at 25°C

蒸汽密度：

1.94 (vs air)

存储条件/存储方法：

库房通风低温干燥,与氧化剂、酸类分开存放,久放变质

稳定性相关：

1.化学性质：丙烯醛兼含有双键和醛基，具有两种官能团的典型反应。丙烯醛的双键可以与醇、硫醇、水、胺、有机酸和无机酸，活泼亚甲基化合物在酸或碱催化下发生加成反应。丙烯醛的醛基可以与醇或多羟基物质在温和的酸性条件下发生缩醛反应。双键与醛基可以相互影响，使丙烯醛表现出特有的性质。

2.本品为刺激性强的极毒液体，强烈地刺激眼和呼吸道黏膜，造成眼结膜炎、喉炎、支气管炎，更高浓度的蒸气能引起肺炎、肺出血、肺水肿和呼吸困难。误服丙烯醛会引起严重肠胃病及肺出血等。亦可经皮肤吸收而中毒。小鼠皮下注射LD5030mg/kg,工作场所空气中最高容许浓度0.25mg/m3。操作人员应戴防护口罩。

3.丙烯醛是一种具有高度刺激性，极毒的液体，在空气中最高容许浓度为0.3mg/m3。直接与其接触会损伤眼睛和呼吸道，是一种很强的催泪毒气。吸入人体会引起肠胃不适、肺充血和水肿。

4.稳定性^[26] 稳定

5.禁配物^[27] 强氧化剂、强还原剂、氧、酸类、碱类、氨、胺类、二氧化硫、硫脲、金属盐类等。

6.避免接触的条件^[28] 受热、光照、接触空气

7.聚合危害^[29] 聚合

其它信息：

1.性状：无色或淡黄色液体，有恶臭。^[1]

2.pH值：6（10%水溶液）^[2]

3.熔点（℃）：-87.7^[3]

4.沸点（℃）：52.5^[4]

5.相对密度（水=1）：0.84^[5]

6.相对蒸气密度（空气=1）：1.94^[6]

7.饱和蒸气压（kPa）：29.33（20℃）^[7]

8.燃烧热（kJ/mol）：-1625.74^[8]

9.临界压力（MPa）：5.06^[9]

10.辛醇/水分配系数：-0.01~0.9^[10]

11.闪点（℃）：-26（CC）^[11]

12.引燃温度（℃）：234^[12]

13.爆炸上限（%）：31.0^[13]

14.爆炸下限（%）：2.8^[14]

15.溶解性：溶于水，易溶于乙醇、丙酮等多数有机溶剂。^[15]

16.黏度（mPa·s,20ºC）：0.35

17.常温折射率（n²⁵）：1.3974^24.5

18.气相标准熵(J·mol^-1·K^-1) ：281.7

19.液相标准燃烧热(焓)(kJ·mol^-1)：-1638.68

20.液相标准声称热(焓)( kJ·mol^-1)：-113.51

21.液相标准热熔(J·mol^-1·K^-1)：121.1

安全信息

外观与性状：

无色至略黄色液体

密度：

0.839 g/mL at 25 °C(lit.)

熔点：

−87 °C(lit.)

沸点：

53 °C(lit.)

闪点：

−2 °F

水溶解性：

Soluble. 21.25 g/100 mL

折射率：

n20/D 1.403(lit.)

蒸汽压：

261mmHg at 25°C

蒸汽密度：

1.94 (vs air)

存储条件/存储方法：

库房通风低温干燥,与氧化剂、酸类分开存放,久放变质

稳定性相关：

1.化学性质：丙烯醛兼含有双键和醛基，具有两种官能团的典型反应。丙烯醛的双键可以与醇、硫醇、水、胺、有机酸和无机酸，活泼亚甲基化合物在酸或碱催化下发生加成反应。丙烯醛的醛基可以与醇或多羟基物质在温和的酸性条件下发生缩醛反应。双键与醛基可以相互影响，使丙烯醛表现出特有的性质。

2.本品为刺激性强的极毒液体，强烈地刺激眼和呼吸道黏膜，造成眼结膜炎、喉炎、支气管炎，更高浓度的蒸气能引起肺炎、肺出血、肺水肿和呼吸困难。误服丙烯醛会引起严重肠胃病及肺出血等。亦可经皮肤吸收而中毒。小鼠皮下注射LD5030mg/kg,工作场所空气中最高容许浓度0.25mg/m3。操作人员应戴防护口罩。

3.丙烯醛是一种具有高度刺激性，极毒的液体，在空气中最高容许浓度为0.3mg/m3。直接与其接触会损伤眼睛和呼吸道，是一种很强的催泪毒气。吸入人体会引起肠胃不适、肺充血和水肿。

4.稳定性^[26] 稳定

5.禁配物^[27] 强氧化剂、强还原剂、氧、酸类、碱类、氨、胺类、二氧化硫、硫脲、金属盐类等。

6.避免接触的条件^[28] 受热、光照、接触空气

7.聚合危害^[29] 聚合

其它信息：

1.性状：无色或淡黄色液体，有恶臭。^[1]

2.pH值：6（10%水溶液）^[2]

3.熔点（℃）：-87.7^[3]

4.沸点（℃）：52.5^[4]

5.相对密度（水=1）：0.84^[5]

6.相对蒸气密度（空气=1）：1.94^[6]

7.饱和蒸气压（kPa）：29.33（20℃）^[7]

8.燃烧热（kJ/mol）：-1625.74^[8]

9.临界压力（MPa）：5.06^[9]

10.辛醇/水分配系数：-0.01~0.9^[10]

11.闪点（℃）：-26（CC）^[11]

12.引燃温度（℃）：234^[12]

13.爆炸上限（%）：31.0^[13]

14.爆炸下限（%）：2.8^[14]

15.溶解性：溶于水，易溶于乙醇、丙酮等多数有机溶剂。^[15]

16.黏度（mPa·s,20ºC）：0.35

17.常温折射率（n²⁵）：1.3974^24.5

18.气相标准熵(J·mol^-1·K^-1) ：281.7

19.液相标准燃烧热(焓)(kJ·mol^-1)：-1638.68

20.液相标准声称热(焓)( kJ·mol^-1)：-113.51

21.液相标准热熔(J·mol^-1·K^-1)：121.1

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

AS1050000

CHEMICAL NAME :

Acrolein

CAS REGISTRY NUMBER :

107-02-8

LAST UPDATED :

199712

DATA ITEMS CITED :

106

MOLECULAR FORMULA :

C3-H4-O

MOLECULAR WEIGHT :

56.07

WISWESSER LINE NOTATION :

VH1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Human

TYPE OF TEST :

Open irritation test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

1 ppm

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

5500 ppb

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

153 ppm/10M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

300 ppb/2H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - respiratory obstruction Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

26 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

18 mg/m3/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic Liver - fatty liver degeneration

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

13900 ug/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

66 ppm/6H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

9008 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

30 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic Liver - fatty liver degeneration

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

1570 mg/m3/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

15 mg/kg

TOXIC EFFECTS :

Blood - other changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

7 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

24 mg/m3/6H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

250 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

24 mg/m3/6H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

178 ug/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - hamster

DOSE/DURATION :

1000 ppm/10M

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

10 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

45 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4 ppm/6H/62D-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4900 ppb/6H/13W-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Endocrine - changes in adrenal weight Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

510 ug/m3/24H/9W-C

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3 ppm/6H/3W-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Endocrine - changes in spleen weight

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

3700 ppb/8H/6W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

3700 ppb/8H/6W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

4900 ppb/6H/13W-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - changes in lung weight

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - hamster

DOSE/DURATION :

4900 ppb/6H/13W-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes Lungs, Thorax, or Respiration - changes in lung weight

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - hamster

DOSE/DURATION :

4 ppm/7H/52W-I

TOXIC EFFECTS :

Brain and Coverings - changes in brain weight Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

840 mg/kg

SEX/DURATION :

multigeneration

TOXIC EFFECTS :

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

DOSE :

6 mg/kg

SEX/DURATION :

female 9 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

Specific locus test

TYPE OF TEST :

Sex chromosome loss and nondisjunction

TYPE OF TEST :

DNA inhibition

TYPE OF TEST :

Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :

DNA inhibition

TEST SYSTEM :

Mammal - species unspecified Lymphocyte

REFERENCE :

FEBLAL FEBS Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1968- Volume(issue)/page/year: 30,286,1973 *** REVIEWS *** ACGIH TLV-STEL 0.69 mg/m3 (0.3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.23 mg/m3 (0.1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,479,1979 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,133,1985 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,133,1985 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,337,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,337,1995 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,78,1987 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,339,1995 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 11,163,1975 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,115,1978 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.1 ppm (0.25 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,5,1971 OSHA PEL (Gen Indu):8H TWA 0.1 ppm (0.25 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.1 ppm (0.25 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.1 ppm (0.25 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.1 ppm (0.25 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 0.1 ppm (0.25 mg/m3);STEL 0.3 ppm (0.8 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.1 ppm (0.23 mg/m3);STEL 0.3 ppm (0.69 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-FINLAND:STEL 0.1 ppm (0.25 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-HUNGARY:TWA 0.25 mg/m3;STEL 0.5 mg/m3 JAN 1993 OEL-INDIA:TWA 0.1 ppm (0.25 mg/m3);STEL 0.3 ppm (0.8 mg/m3) JAN 1993 OEL-JAPAN:TWA 0.1 ppm (0.23 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-POLAND:TWA 0.5 mg/m3 JAN 1993 OEL-RUSSIA:TWA 0.1 ppm;STEL 0.2 mg/m3 JAN 1993 OEL-SWEDEN:TWA 0.1 ppm (0.2 mg/m3);STEL 0.3 ppm (0.7 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.25 mg/m3);STEL 0.2 ppm JAN 1993 OEL-TURKEY:TWA 0.1 ppm (0.25 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.25 mg/m3);STEL 0.3 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ACROLEIN-air:10H TWA 0.1 ppm;STEL 0.3 ppmREFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 03530 No. of Facilities: 845 (estimated) No. of Industries: 16 No. of Occupations: 25 No. of Employees: 7299 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 03530 No. of Facilities: 37 (estimated) No. of Industries: 4 No. of Occupations: 18 No. of Employees: 1298 (estimated) No. of Female Employees: 5 (estimated)

毒理学数据：

1.急性毒性^[16]

LD50：26mg/kg（大鼠经口）；14mg/kg（小鼠经口）；7mg/kg（兔经口）；200mg/kg（兔经皮）

LC50：18mg/m³（大鼠吸入，4h）

2.刺激性^[17]

家兔经皮：5mg，重度刺激。

家兔经眼：1mg，重度刺激。

3.亚急性与慢性毒性^[18] 大鼠持续接触本品浓度4.8mg/m³,40h后，其肝脏的碱性磷酸酶活性升高。

4.致突变性^[19] 人细胞DNA损伤：30μmol/L。人淋巴细胞姐妹染色体交换：5μmol/L。

5.致畸性^[20] 如果直接在羊膜上给药，丙烯醛可致畸和产生胚胎毒性。

6.致癌性^[21] IARC致癌性评论：G3，对人及动物致癌性证据不足。

7.其他^[22] 大鼠静脉最低中毒剂量（TDLo）：6mg/kg（孕后用药9d），胚泡植入后死亡率升高。

生态数据：

1.生态毒性^[23]

LC50：0.046mg/L（24h）（褐鳟）；0.079mg/L（24h）（金鱼）；0.0173~0.022mg/L（96h）（黑头呆鱼）；0.23mg/L（24h），0.083mg/L（48h）（水蚤）

LD50：＜0.08mg/L（24h）（金鱼，改良ASTMD1345）

EC50：0.034mg/L（48h）（水蚤）

2.生物降解性^[24]

好氧生物降解（h）：168~672

厌氧生物降解（h）：672~2880

3.非生物降解性^[25] 空气中光氧化半衰期（h）：3.4~33.7

MSDS

国标编号:	31024
ＣＡＳ:	107-02-8
中文名称:	丙烯醛
英文名称:	acrolein；allylaldehyde
别 名:	烯丙醛
分子式:	C3H4O；CH2CHCHO
分子量:	56.06
熔 点:	-87.7℃ 沸点：52.5℃
密 度:	相对密度(水=1)0.84；
蒸汽压:	-26℃
溶解性:	溶于水，易溶于醇、丙酮等多数有机溶剂
稳定性:	不稳定
外观与性状:	无色或淡黄色液体，有恶臭
危险标记:	7(低闪点易燃液体)
用 途:	为合成树脂工业的重要原料之一，也大量用于有机合成与药物合成

2.对环境的影响:
一、健康危害
 侵入途径：吸入、食入、经皮吸收。
健康危害：本品有强烈刺激性。吸入蒸气损害呼吸道，出现咽喉炎、胸部压迫感、支气管炎；大量吸入可致肺炎、肺水肿，尚可出现休克、肾炎及心力衰竭。可致死。液体及蒸气损害眼睛；皮肤接触可致灼伤。口服引起口腔及胃刺激或灼伤。
二、毒理学资料及环境行为
毒性：属高毒类。
急性毒性：LD₅₀46mg/kg(大鼠经口)；562mg/kg(兔经皮)；LC₅₀300mg/m³，1/2小时(大鼠吸入)人吸入2.3mg/m³×5分钟，不能忍受；人吸入153ppm×10分钟，最小致死浓度；人经口5mg/kg最小致死剂量。
  刺激性：家兔经眼：1mg，重度刺激。家兔经皮：5mg，重度刺激。
  亚急性和慢性毒性：大鼠持续接触本品浓度低至4.8mg/m³，40小时后，其肝脏的碱性磷酸酶活性升高。
  致突变性：微生物致突变性：鼠伤寒沙门氏菌20nL/皿。微粒体致突变：鼠伤寒沙门氏菌50µl/皿。
  生殖毒性：大鼠静脉最低中毒剂量(TDL₀)：6mg/kg(孕后用药9天)，胚泡植入后死亡率升高。
致癌性：IARC致癌性评论：动物为不肯定性反应。
  危险特性：其蒸气与空气可形成爆炸性混合物，遇明火、高热极易燃烧爆炸。受热分解释出高毒蒸气。在空气中久置后能生成具有爆炸性的过氧化物。与酸类、碱类、氨、胺类、二氧化硫、硫脲、金属盐类、氧化剂等猛烈反应。在火场高温下能发生聚合放热，使容器破裂。
燃烧(分解)产物：一氧化碳、二氧化碳。
3.现场应急监测方法:
检气管法《化工企业空气中有害物质测定方法》，化学工业出版社
4.实验室监测方法:

监测方法	来源	类别
气相色谱法	HJ/T39-1999	固定污染源排气
气相色谱法	《水质分析大全》张宏陶等主编	水质
气相色谱法	《固体废弃物试验与分析评价手册》中国环境监测总站等译	固体废弃物
4-已基间苯二酚分光光度法	《空气和废气监测分析方法》国家环保局编	空气和废气

5.环境标准:

中国(TJ36-79)	车间空气中有害物质的最高容许浓度	0.3mg/m3
中国(TJ36-79)	居住区大气中有害物质的最高容许浓度	0.10mg/m3(一次值)
中国(GB16297-1996)	大气污染物综合排放标准	①最高允许排放浓度(mg/m3)： 16(表2)；20(表1) ②最高允许排放速率(kg/h)： 二级0.52～11(表2)；0.61～13(表1) 三级0.78～17(表2)；0.92～20(表1) ③无组织排放监控浓度限值(mg/m3)： 0.40(表2)；0.50(表1)
中国(GB11607-89)	渔业水质标准	0.02mg/L
中国(GB5048-92)	农田灌溉水质标准	0.5mg/L(水作、旱作、蔬菜)
中国(待颁布)	饮用水源中有害物质的最高容许浓度	0.1mg/L
	嗅觉阈浓度	0.48～4.1mg/m3

6.应急处理处置方法:
一、泄漏应急处理  
迅速撤离泄漏污染区人员至安全区，并立即进行隔离，小泄漏时隔离150米，大泄漏时隔离300米，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿防毒服。不要直接接触泄漏物。尽可能切断泄漏源。防止进入下水道、排洪沟等限制性空间。小量泄漏：用活性面料或其它惰性材料吸收。也可以用大量水冲洗，洗水稀释后放入废水系统。大量泄漏：构筑围堤或挖坑收容；用泡沫覆盖，降低蒸气灾害。用防爆泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。
二、防护措施
呼吸系统防护：可能接触其蒸气时，必须佩戴自吸过滤式防毒面具(全面罩)。
眼睛防护：呼吸系统防护中已作防护。
身体防护：穿防静电工作服。
手防护：戴橡胶手套。
其它：工作现场禁止吸烟、进食和饮水。工作毕，淋浴更衣。保持良好的卫生习惯。
三、急救措施
 皮肤接触：立即脱去被污染的衣着，用大量流动清水冲洗，至少15分钟。
 眼睛接触：立即提起眼睑，用大量流动清水或生理盐水彻底冲洗至少15分钟。就医。
 吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
 食入：误服者用水漱口，给饮牛奶或蛋清。就医。
 灭火方法：消防人员须戴好防毒面具，在安全距离以外，在上风向灭火。灭火剂：在抗溶性泡沫、干粉、二氧化碳、砂土。用水灭火无效。

分子结构与计算化学数据

分子结构数据

1、摩尔折射率：15.85

2、摩尔体积（cm³/mol）：70.4

3、等张比容（90.2K）：149.3

4、表面张力（dyne/cm）：20.1

5、介电常数：

6、偶极距（10^-24cm³）：

7、极化率：6.28

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:1

4.可旋转化学键数量:1

5.互变异构体数量:无

6.拓扑分子极性表面积17.1

7.重原子数量:4

8.表面电荷:0

9.复杂度:30.3

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1