pseudoephedrine hydrochloride

物化性质

外观与性状：

白色结晶粉末

熔点：

181-182ºC

沸点：

255ºC at 760mmHg

闪点：

85.6ºC

存储条件/存储方法：

密封储存，冷藏，储存于阴凉、干燥的库房。

稳定性相关：

常温常压下稳定。避免与光照，强氧化剂接触。

其它信息：

1. 性状：白色结晶状粉末

2. 密度（g/mL,20℃）：1.198

3. 相对蒸汽密度（g/mL,空气=1）：未确定

4. 熔点（ºC）：185-188

5. 沸点（ºC,常压）：未确定

6. 沸点（ºC,5mmHg）：未确定

7. 折射率(n20/D)：未确定

8. 闪点（ºF）：未确定

9. 比旋光度（º）：61

10. 自燃点或引燃温度（ºC）：未确定

11. 蒸气压（mmHg,25ºC）：未确定

12. 饱和蒸气压（kPa,83-85ºC）：未确定

13. 燃烧热（KJ/mol）：未确定

14. 临界温度（ºC）：未确定

15. 临界压力（KPa）：未确定

16. 油水（辛醇/水）分配系数的对数值：未确定

17. 爆炸上限（%,V/V）：未确定

18. 爆炸下限（%,V/V）：未确定

19. 溶解性：未确定

安全信息

外观与性状：

白色结晶粉末

熔点：

181-182ºC

沸点：

255ºC at 760mmHg

闪点：

85.6ºC

存储条件/存储方法：

密封储存，冷藏，储存于阴凉、干燥的库房。

稳定性相关：

常温常压下稳定。避免与光照，强氧化剂接触。

其它信息：

1. 性状：白色结晶状粉末

2. 密度（g/mL,20℃）：1.198

3. 相对蒸汽密度（g/mL,空气=1）：未确定

4. 熔点（ºC）：185-188

5. 沸点（ºC,常压）：未确定

6. 沸点（ºC,5mmHg）：未确定

7. 折射率(n20/D)：未确定

8. 闪点（ºF）：未确定

9. 比旋光度（º）：61

10. 自燃点或引燃温度（ºC）：未确定

11. 蒸气压（mmHg,25ºC）：未确定

12. 饱和蒸气压（kPa,83-85ºC）：未确定

13. 燃烧热（KJ/mol）：未确定

14. 临界温度（ºC）：未确定

15. 临界压力（KPa）：未确定

16. 油水（辛醇/水）分配系数的对数值：未确定

17. 爆炸上限（%,V/V）：未确定

18. 爆炸下限（%,V/V）：未确定

19. 溶解性：未确定

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

UL5950000

CHEMICAL NAME :

Pseudoephedrine, hydrochloride, L-(+)-

CAS REGISTRY NUMBER :

345-78-8

LAST UPDATED :

199701

DATA ITEMS CITED :

10

MOLECULAR FORMULA :

C10-H15-N-O.Cl-H

MOLECULAR WEIGHT :

201.72

WISWESSER LINE NOTATION :

QYR&Y1&M1 &GH -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

714 ug/kg

TOXIC EFFECTS :

Vascular - BP elevation not characterized in autonomic section

REFERENCE :

AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 39,404,1927

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

80 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

371 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 60,1523,1971

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

202 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 158,135,1967

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Parenteral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

400 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

MAIZAB Manshu Igaku Zasshi. Manchuria Medical Journal. (Dairen/Shimmeicho, South Manchuria) V.1-33, 1923-40. Discontinued. Volume(issue)/page/year: 3,1,1925

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

75 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 36,363,1929

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Parenteral

SPECIES OBSERVED :

Amphibian - frog

DOSE/DURATION :

800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Mn,128,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81961 No. of Facilities: 1053 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 4276 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81961 No. of Facilities: 380 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 13961 (estimated) No. of Female Employees: 10517 (estimated)

毒理学数据：

1、急性毒性：人经口TDLo：714μg/kg；大鼠经皮下LDLo：80mg/kg；小鼠经口LD50：371mg/kg；小鼠经腹腔LD50：202mg/kg；小鼠经肠外LDLo：400mg/kg；兔子经静脉LDLo：75mg/kg；青蛙经肠外LDLo：800mg/kg；

MSDS

Name:	(1S 2S)-(+)-Pseudoephedrine hydrochloride Material Safety Data Sheet
Synonym:	D-Pseudoephedrine hydrochloride
CAS:	345-78-8

Section 1 - Chemical Product   MSDS Name:(1S 2S)-(+)-Pseudoephedrine hydrochloride Material Safety Data Sheet
Synonym:D-Pseudoephedrine hydrochloride
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
345-78-8	(1S,2S)-(+)-Pseudoephedrine hydrochlor	99+	206-462-1

Hazard Symbols: XN
Risk Phrases: 22 36/37/38
Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Harmful if swallowed. Irritating to eyes, respiratory system and skin.Light sensitive.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
The toxicological properties of this substance have not been fully investigated. May cause central nervous system effects and/or neurological effects.
Inhalation:
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled.
Chronic:
Prolonged or repeated exposure can cause psychic abnormalities such as anxiety, depression and excitability. Prolonged exposure may cause mental changes such as hallucinations, depression, psychosis, and possibly coma. Repeated or prolonged exposure may cause CNS stimulation.
Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.
Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Use only in a well-ventilated area.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.
Storage:
Keep refrigerated. (Store below 4C/39F.) Store protected from moisture. Store protected from light.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 345-78-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 183-186 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H15NOClH
Molecular Weight: 201.7
Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures. Sensitive to light.
Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid:
Light, dust generation, exposure to moist air or water.
Incompatibilities with Other Materials:
Oxidizing agents, acids, acetic anhydride, acid chlorides.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 345-78-8: UL5950000 LD50/LC50:
CAS# 345-78-8: Oral, mouse: LD50 = 371 mg/kg.
Carcinogenicity:
(1S,2S)-(+)-Pseudoephedrine hydrochloride - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
 
Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:
Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 345-78-8: No information available.
Canada
CAS# 345-78-8 is listed on Canada's DSL List.
CAS# 345-78-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 345-78-8 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

海关数据

中国海关编码：2922199090

概述：

2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

申报要素：

品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

摘要/Summary：

2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

分子结构与计算化学数据

计算化学数据

1、 疏水参数计算参考值（XlogP）：

2、 氢键供体数量：3

3、 氢键受体数量：2

4、 可旋转化学键数量：3

5、 互变异构体数量：

6、 拓扑分子极性表面积（TPSA）：32.3

7、 重原子数量：13

8、 表面电荷：0

9、 复杂度：121

10、同位素原子数量：0

11、确定原子立构中心数量：2

12、不确定原子立构中心数量：0

13、确定化学键立构中心数量：0

14、不确定化学键立构中心数量：0

15、共价键单元数量：2