英语词典化工词典

methamidophos

methamidophos

  • 中文别名：甲胺磷
  • 中文释义：甲胺磷;多灭磷;多灭灵乳油;O,S-二甲基胺基硫代磷酸酯
  • 英文别名：methamidophos;
    Methamidophos PESTANAL(R),analytical standard;
    (Ξ)-(O,S-dimethyl phosphoramidothioate);
    O,S-dimethyl phosphoramidothioate;
    Tam;
    O,S-dimethyl phosphoamidothioate;
    Prodex;
    Filitox;
    Tamanox;
    metamidophos;
    Hamidop;
    Methamidophos;
    (RS)-(O,S-dimethyl phosphoramidothioate);
    Nitofol;
    O,S-dimethyl phosphoroamidothioate;
    GIANT;
    re9006;
    ckb1220 
  • CAS No.：10265-92-6
  • 分子式：

    C2H8NO2PS

  • 分子量：141.12900
  • 精确分子量：141.00100
  • PSA：87.43000
  • MDL：MFCD00041808
  • InChI：InChI=1/C2H8NO2PS/c1-5-6(3,4)7-2/h1-2H3,(H2,3,4)
  • 分子结构式：

物化性质

外观与性状：
无色晶体
密度：
1.286 g/cm3
熔点：
44.5°C
沸点：
208.7ºC at 760 mmHg
闪点：
212 °C
折射率：
1.485
蒸汽压：
0.211mmHg at 25°C
存储条件/存储方法：
库房通风低温干燥,与食品原料分开储运
稳定性相关：

1.稳定性[14] 稳定

2.禁配物[15] 强氧化剂、强碱

3.避免接触的条件[16] 受热

4.聚合危害[17] 不聚合

5.分解产物[18] 氨、氧化磷

其它信息：

1.性状：纯品为白色针状晶体，工业品为无色黏稠状液体，冷却或放置后能析出针状结晶。[1]

2.熔点（℃）：43（纯）；18~25（工业品）[2]

3.相对密度（水=1）：1.31[3]

4.饱和蒸气压（kPa）：0.00004（30℃）[4]

5.辛醇/水分配系数：-0.8[5]

6.闪点（℃）：93[6]

7.溶解性：微溶于水，溶于醇类、氯化烃，微溶于乙醚。[7]

安全信息

外观与性状：
无色晶体
密度：
1.286 g/cm3
熔点：
44.5°C
沸点：
208.7ºC at 760 mmHg
闪点：
212 °C
折射率：
1.485
蒸汽压：
0.211mmHg at 25°C
存储条件/存储方法：
库房通风低温干燥,与食品原料分开储运
稳定性相关：

1.稳定性[14] 稳定

2.禁配物[15] 强氧化剂、强碱

3.避免接触的条件[16] 受热

4.聚合危害[17] 不聚合

5.分解产物[18] 氨、氧化磷

其它信息：

1.性状：纯品为白色针状晶体，工业品为无色黏稠状液体，冷却或放置后能析出针状结晶。[1]

2.熔点（℃）：43（纯）；18~25（工业品）[2]

3.相对密度（水=1）：1.31[3]

4.饱和蒸气压（kPa）：0.00004（30℃）[4]

5.辛醇/水分配系数：-0.8[5]

6.闪点（℃）：93[6]

7.溶解性：微溶于水，溶于醇类、氯化烃，微溶于乙醚。[7]

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TB4970000
CHEMICAL NAME :
Phosphoramidothioic acid, O,S-dimethyl ester
CAS REGISTRY NUMBER :
10265-92-6
LAST UPDATED :
199710
DATA ITEMS CITED :
31
MOLECULAR FORMULA :
C2-H8-N-O2-P-S
MOLECULAR WEIGHT :
141.14
WISWESSER LINE NOTATION :
1SPZS&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
257 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Skin and Appendages - sweating
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Skin and Appendages - sweating
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Autonomic Nervous System - parasympatholytic Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
162 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
118 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
57500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - domestic
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
71890 ug/kg/13W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - mouse Cells - not otherwise specified
DOSE/DURATION :
250 ug/L
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep. Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989
毒理学数据：

1.急性毒性[8]

LD50：20~29.9mg/kg（大鼠经口）；50mg/kg（大鼠经皮）

LC50：525mg/m3（大鼠吸入，1h）；19mg/m3（小鼠吸入）

2.刺激性 暂无资料

3.致突变性[9] 微核试验：小鼠腹腔6mg/kg；小鼠经口84mg/kg（周）（连续）；小鼠经皮96mg/kg（2周）（间歇）。姐妹染色单体交换：小鼠腹腔6mg/kg。

4.致畸性[10] 大鼠孕后6~15d经口给予最低中毒剂量（TDLo）10mg/kg，致中枢神经系统、眼、耳发育畸形。大鼠孕后1~6d经口给予最低中毒剂量（TDLo）6mg/kg，致眼、耳、皮肤及附属组织、泌尿生殖系统发育畸形。

5.其他[11] 大鼠经口最低中毒剂量（TDLo）：10mg/kg（孕6~16d用药），致胚胎毒性，中枢神经系统发育异常，眼、耳发育异常。

生态数据：

1.该物质对环境可能有危害，对水体应给予特别注意。

2.生态毒性[12]

LC50：25ppm（96h）（虹鳟鱼，静态）；

34ppm（96h）（蓝鳃太阳鱼，静态）；

300ng/L（12h），85ng/L（24h），2.4ng/L（36h）（南美蓝对虾）

EC50：39ppb（96h）（牡蛎）

3.生物降解性 暂无资料

4.非生物降解性[13] 空气中，当羟基自由基浓度为5.00×105个/cm3时，降解半衰期为12h（理论）。

在22℃，当pH值为4，7，9时，水解半衰期分别为1.8a，120h，70h（理论）。

海关数据

中国海关编码：2930500010

概述：
2930500010 甲胺磷(ISO) 退税率:0.0% 监管条件:X(有毒化学品环境管理放行通知单)
摘要/Summary：
2930500010 o,s-dimethyl phosphoramidothioate

分子结构与计算化学数据

分子结构数据

1、 摩尔折射率：31.46

2、 摩尔体积（cm3/mol）：109.7

3、 等张比容（90.2K）：283.1

4、 表面张力（dyne/cm）：44.4

5、 极化率（10-24cm3）：12.47

计算化学数据

1.疏水参数计算参考值（XlogP）:-0.9

2.氢键供体数量:1

3.氢键受体数量:4

4.可旋转化学键数量:2

5.互变异构体数量:2

6.拓扑分子极性表面积77.6

7.重原子数量:7

8.表面电荷:0

9.复杂度:95.7

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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