cinchocaine

物化性质

密度：

1.026 g/mL at 25 °C(lit.)

熔点：

-51 °C

沸点：

229.5 °C766 mm Hg(lit.)

闪点：

209 °F

折射率：

n20/D 1.501(lit.)

其它信息：

一、物性数据

1. 性状：不确定。

2. 密度（g/mL,25/4℃）：不确定

3. 相对蒸汽密度（g/mL,空气=1）：不确定

4. 熔点（ºC）：不确定

5. 沸点（ºC,常压）：不确定

6. 沸点（ºC,5.2kPa）：不确定

7. 折射率：不确定

8. 闪点（ºC）：不确定

9. 比旋光度（º）：不确定

10. 自燃点或引燃温度（ºC）：不确定

11. 蒸气压（kPa,25ºC）：不确定

12. 饱和蒸气压（kPa,60ºC）：不确定

13. 燃烧热（KJ/mol）：不确定

14. 临界温度（ºC）：不确定

15. 临界压力（KPa）：不确定

16. 油水（辛醇/水）分配系数的对数值：不确定

17. 爆炸上限（%,V/V）：不确定

18. 爆炸下限（%,V/V）：不确定

19. 溶解性：不确定。

安全信息

密度：

1.026 g/mL at 25 °C(lit.)

熔点：

-51 °C

沸点：

229.5 °C766 mm Hg(lit.)

闪点：

209 °F

折射率：

n20/D 1.501(lit.)

其它信息：

一、物性数据

1. 性状：不确定。

2. 密度（g/mL,25/4℃）：不确定

3. 相对蒸汽密度（g/mL,空气=1）：不确定

4. 熔点（ºC）：不确定

5. 沸点（ºC,常压）：不确定

6. 沸点（ºC,5.2kPa）：不确定

7. 折射率：不确定

8. 闪点（ºC）：不确定

9. 比旋光度（º）：不确定

10. 自燃点或引燃温度（ºC）：不确定

11. 蒸气压（kPa,25ºC）：不确定

12. 饱和蒸气压（kPa,60ºC）：不确定

13. 燃烧热（KJ/mol）：不确定

14. 临界温度（ºC）：不确定

15. 临界压力（KPa）：不确定

16. 油水（辛醇/水）分配系数的对数值：不确定

17. 爆炸上限（%,V/V）：不确定

18. 爆炸下限（%,V/V）：不确定

19. 溶解性：不确定。

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

GD3150000

CHEMICAL NAME :

Cinchoninamide, 2-butoxy-N-(2-(diethylamino)ethyl)-

CAS REGISTRY NUMBER :

85-79-0

BEILSTEIN REFERENCE NO. :

0275489

LAST UPDATED :

199706

DATA ITEMS CITED :

12

MOLECULAR FORMULA :

C20-H29-N3-O2

MOLECULAR WEIGHT :

343.52

WISWESSER LINE NOTATION :

T66 BNJ CO4 EVM2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,209,1969

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

7 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,156,1959

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

24500 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,925,1960

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

28500 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,925,1960

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

6 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 39,4,1950

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

8500 ug/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 29,368,1932

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

2500 ug/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 29,368,1932

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intraspinal

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

2100 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 54,137,1935

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

112 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intraspinal

SPECIES OBSERVED :

Amphibian - frog

DOSE/DURATION :

4 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 45,291,1932 *** REVIEWS *** TOXICOLOGY REVIEW PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5147 No. of Facilities: 351 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 37962 (estimated) No. of Female Employees: 36068 (estimated)

毒理学数据：

1、急性毒性：

小孩口径LDLO; 50mg/kg；

大鼠腹腔LD50：7mg/kg；

小鼠腹腔LD50：24500 ug/kg；小鼠皮下LD50：28500 ug/kg

小鼠静脉LDL0：6mg/kg

兔子皮下LD50：8500 ug/kg；兔子静脉LD50：2100 ug/kg；

猪皮下LDL0：112mg/kg

青蛙脊柱LDL0：4mg/kg

MSDS

Section 1. Chemical Product and Company Identification
Dibucaine
Common Name/
Trade Name
Dibucaine
Section 3. Hazards Identification
Potential Acute HealthHazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant),
Effectsof inhalation. Severe over-exposure can result in death.
CARCINOGENIC EFFECTS: Not available.
Potential Chronic Health
MUTAGENIC EFFECTS: Not available.
Effects
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance may be toxic to cardiovascular system, central nervous system (CNS).
Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure
to a highly toxic material may produce general deterioration of health by an accumulation in one or many
human organs.
Section 4. First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water
for at least 15 minutes. Get medical attention if irritation occurs.
Skin ContactIn case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse.
Thoroughly clean shoes before reuse. Get medical attention immediately.
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical attention immediately.
Serious InhalationEvacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth
resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth
resuscitation when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention.
IngestionIf swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical
attention immediately.
Serious IngestionNot available.
Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash PointsNot available.
Flammable LimitsNot available.
Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances
Explosion Hazards inRisks of explosion of the product in presence of mechanical impact: Not available.
Presence of VariousRisks of explosion of the product in presence of static discharge: Not available.
Substances
Fire Fighting MediaSMALL FIRE: Use DRY chemical powder.
and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks onWhen heated to decomposition it emits toxic fumes of nitroxides.
Fire Hazards
Special Remarks on Explosion Not available.
Hazards
Dibucaine
Section 6. Accidental Release Measures
Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container.
Large SpillPoisonous solid.
Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray
to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all
Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do
Precautions
not ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice
immediately and show the container or the label.
StorageKeep container tightly closed. Keep container in a cool, well-ventilated area.
Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels
below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep
exposure to airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be
a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product.
Exposure LimitsNot available.
Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Hygroscopic powder.)OdorOdorless.
Not available.
Taste
343.46 g/mole
Molecular Weight
ColorWhite.
Not applicable.
pH (1% soln/water)
Boiling PointNot available.
Melting Point62°C (143.6°F) - 65 C.
Critical TemperatureNot available.
Specific GravityNot available.
Not applicable.
Vapor Pressure
Vapor Density13.1 (Air = 1)
Not available.
Volatility
Odor ThresholdNot available.
Water/Oil Dist. Coeff.Not available.
Not available.
Ionicity (in Water)
Dispersion PropertiesSee solubility in water, diethyl ether.
Soluble in diethyl ether.
Solubility
Insoluble in cold water, hot water.
Soluble in Ethanol, Chloroform, Petroleum Ether
Dibucaine
Section 10. Stability and Reactivity Data
The product is stable.
Stability
Instability TemperatureNot available.
Excess heat
Conditions of Instability
Incompatibility with various Not available.
substances
Non-corrosive in presence of glass.
Corrosivity
Special Remarks onSensitive to light.
Reactivity
Special Remarks onNot available.
Corrosivity
Will not occur.
Polymerization
Section 11. Toxicological Information
Routes of EntryInhalation. Ingestion.
Toxicity to AnimalsLD50: Not available.
LC50: Not available.
Chronic Effects on Humans May cause damage to the following organs: cardiovascular system, central nervous system (CNS).
Other Toxic Effects onHazardous in case of ingestion.
HumansSlightly hazardous in case of skin contact (irritant), of inhalation.
Special Remarks onNot available.
Toxicity to Animals
Special Remarks onNot available.
Chronic Effects on Humans
Special Remarks on otherAcute Potential Health Effects:
Toxic Effects on HumansSkin: May cause skin irritation. Can cause local numbness.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritation.
Ingestion: Harmful if swallowed. Can cause vomiting, pallor, increased sweating, blurred or double vision.
May affect behavior/'central nervous system (headache, staggering, convulsions, dizziness, confusion,
drowsiness, trembling, shivering, anxiety, tiredness, weakness, excitement, somnolence), cardiovascular
system (low blood pressure, irregular heartbeat, cardiac arresst). May also cause ringning or buzzing in the
ears, feeling hot or cold, or numb.
Medical Conditions Aggravated by Exposure: hypersensitivity to material; hear disease; chronic obstructive
lung disease.
Section 12. Ecological Information
EcotoxicityNot available.
BOD5 and CODNot available.
Possibly hazardous short term degradation products are not likely. However, long term degradation
Products of Biodegradation
products may arise.
The products of degradation are less toxic than the product itself.
Toxicity of the Products
of Biodegradation
Special Remarks on theNot available.
Products of Biodegradation
Dibucaine
Section 13. Disposal Considerations
Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental
control regulations.
Section 14. Transport Information
DOT ClassificationCLASS 6.1: Poisonous material.
UNNA: 1544 : Alkaloid, solid, n.o.s. (Dibucaine) PG: III
Identification
Not available.
Special Provisions for
Transport
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has
Proposition 65found to cause cancer which would require a warning under the statute: No products were found.
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has
found to cause birth defects which would require a warning under the statute: No products were found.
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Regulations
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS
no. 201-632-1)
Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance
List (NDSL).
China: Not listed on National Inventory.
Japan: Not listed on National Inventory (ENCS).
Korea: Not listed on National Inventory (KECI).
Philippines: Not listed on National Inventory (PICCS).
Australia: Listed on AICS.
WHMIS (Canada) CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
Other Classifications
DSCL (EEC)This product is not classifiedNot applicable.
according to the EU regulations.
Health Hazard
HMIS (U.S.A.)2 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
2 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
Dibucaine
TDG (Canada)
(Pictograms)
6
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
SECTION 16 - ADDITIONAL INFORMATION
N/A

海关数据

中国海关编码：2933499090

概述：

2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素：

品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

摘要/Summary：

2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

分子结构与计算化学数据

分子结构数据

五、分子性质数据：

1、 摩尔折射率：103.27

2、 摩尔体积（m³/mol）：320.4

3、 等张比容（90.2K）：819.0

4、 表面张力（dyne/cm）：42.6

5、 极化率（10^-24cm³）：40.94

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:1

3.氢键受体数量:4

4.可旋转化学键数量:10

5.互变异构体数量:2

6.拓扑分子极性表面积54.5

7.重原子数量:25

8.表面电荷:0

9.复杂度:387

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1