phosphane

物化性质

外观与性状：

无色气体

密度：

1.15 (vs air)

熔点：

-133.78ºC

沸点：

-87.5ºC(lit.)

存储条件/存储方法：

库房通风低温干燥,轻装轻卸,与氧气、空气等助燃气体钢瓶分开存放

稳定性相关：

1.在空气中约150℃着火，但混入P2H4时常温下也会着火。一体积水可吸收0.112体积的PH3(常温)。

2.稳定性^[18] 稳定

3.禁配物^[19] 强氧化剂

4.避免接触的条件^[20] 空气

5.聚合危害^[21] 不聚合

其它信息：

1.性状：无色，有类似大蒜气味的气体。^[1]

2.熔点（℃）：-133^[2]

3.沸点（℃）：-87.7^[3]

4.相对密度（水=1）：0.8^[4]

5.相对蒸气密度（空气=1）：1.17^[5]

6.饱和蒸气压（kPa）：53.32（-98.3℃）^[6]

7.临界温度（℃）：52^[7]

8.临界压力（MPa）：6.58^[8]

9.辛醇/水分配系数：-0.27^[9]

10.闪点（℃）：-88^[10]

11.引燃温度（℃）：100~150^[11]

12.爆炸上限（%）：98^[12]

13.爆炸下限（%）：1.8^[13]

14.溶解性：不溶于热水，微溶于冷水，溶于乙醇、乙醚。^[14]

安全信息

外观与性状：

无色气体

密度：

1.15 (vs air)

熔点：

-133.78ºC

沸点：

-87.5ºC(lit.)

存储条件/存储方法：

库房通风低温干燥,轻装轻卸,与氧气、空气等助燃气体钢瓶分开存放

稳定性相关：

1.在空气中约150℃着火，但混入P2H4时常温下也会着火。一体积水可吸收0.112体积的PH3(常温)。

2.稳定性^[18] 稳定

3.禁配物^[19] 强氧化剂

4.避免接触的条件^[20] 空气

5.聚合危害^[21] 不聚合

其它信息：

1.性状：无色，有类似大蒜气味的气体。^[1]

2.熔点（℃）：-133^[2]

3.沸点（℃）：-87.7^[3]

4.相对密度（水=1）：0.8^[4]

5.相对蒸气密度（空气=1）：1.17^[5]

6.饱和蒸气压（kPa）：53.32（-98.3℃）^[6]

7.临界温度（℃）：52^[7]

8.临界压力（MPa）：6.58^[8]

9.辛醇/水分配系数：-0.27^[9]

10.闪点（℃）：-88^[10]

11.引燃温度（℃）：100~150^[11]

12.爆炸上限（%）：98^[12]

13.爆炸下限（%）：1.8^[13]

14.溶解性：不溶于热水，微溶于冷水，溶于乙醇、乙醚。^[14]

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SY7525000

CHEMICAL NAME :

Phosphine

CAS REGISTRY NUMBER :

7803-51-2

LAST UPDATED :

199712

DATA ITEMS CITED :

49

MOLECULAR FORMULA :

H3-P

MOLECULAR WEIGHT :

34.00

WISWESSER LINE NOTATION :

H3 P

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

1000 ppm/5M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

11 ppm/4H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

380 mg/m3/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

70 mg/m3/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

2500 ppm/20M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

140 mg/m3/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

1000 ppm/5M

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

200 ug/m3/24H/6W-C

TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS Blood - pigmented or nucleated red blood cells Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3100 ppb/6H/13W-I

TOXIC EFFECTS :

Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

10 ppm/4H/4D-I

TOXIC EFFECTS :

Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5 ppm/4H/2W-I

TOXIC EFFECTS :

Cardiac - changes in heart weight Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

10 ppm/4H/4D-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5 ppm/4H/2W-I

TOXIC EFFECTS :

Cardiac - changes in heart weight Lungs, Thorax, or Respiration - changes in lung weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

MUTATION DATA

TEST SYSTEM :

Rodent - mouse

REFERENCE :

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,81,1994 *** REVIEWS *** ACGIH TLV-STEL 1.4 mg/m3 (1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.42 mg/m3 (0.3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD778-725 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.3 ppm (0.4 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,209,1971 OSHA PEL (Gen Indu):8H TWA 0.3 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.3 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.3 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.3 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 0.3 ppm (0.4 mg/m3);STEL 1 ppm (1 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.3 ppm (0.42 mg/m3);STEL 1 ppm (1.4 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.15 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.1 ppm (0.15 mg/m3);STEL 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-FRANCE:TWA 0.1 ppm (0.13 mg/m3);STEL 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.1 ppm (0.15 mg/m3) JAN 1993 OEL-HUNGARY:TWA 0.1 mg/m3;STEL 0.2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.3 ppm (0.4 mg/m3);STEL 1 ppm JAN 1993 OEL-THE PHILIPPINES:TWA 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-POLAND:TWA 0.1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.15 mg/m3);STEL 0.2 ppm JAN 1993 OEL-THAILAND:TWA 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-TURKEY:TWA 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-UNITED KINGDOM:STEL 0.3 ppm (0.4 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHOSPHINE-air:10H TWA 0.3 ppm;STEL 1.0 ppmREFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

毒理学数据：

1.急性毒性^[15] LC50：15.3mg/m³（大鼠吸入，4h）

2.刺激性 暂无资料

3.亚急性与慢性毒性^[16] 大鼠吸入7mg/m³,27~36h，死亡；3.5mg/m³，存活；1.4mg/m³,3d，存活。

4.其他^[17] LCLo：1000ppm（人吸入5min）

生态数据：

1.生态毒性 暂无资料

2.生物降解性 暂无资料

3.非生物降解性 暂无资料

MSDS

第一部分：化学品名称

分子结构与计算化学数据

分子结构数据

1、摩尔折射率：无可用的

2、摩尔体积（cm³/mol）：无可用的

3、等张比容（90.2K）：无可用的

4、表面张力（dyne/cm）：无可用的

5、介电常数：无可用的

6、极化率（10^-24cm³）：无可用的

7、单一同位素质量：33.997236 Da

8、标称质量：34 Da

9、平均质量：33.9976 Da

计算化学数据

1、疏水参数计算参考值（XlogP）：-0.1

2、氢键供体数量：0

3、氢键受体数量：0

4、可旋转化学键数量：0

5、互变异构体数量：无

6、拓扑分子极性表面积（TPSA）：0

7、重原子数量：1

8、表面电荷：0

9、复杂度：0

10、同位素原子数量：0

11、确定原子立构中心数量：0

12、不确定原子立构中心数量：0

13、确定化学键立构中心数量：0

14、不确定化学键立构中心数量：0

15、共价键单元数量：1