lidocaine hydrochloride monohydrate

物化性质

外观与性状：

固体

熔点：

68.5ºC

沸点：

350.8ºC at 760 mmHg

闪点：

166ºC

安全信息

外观与性状：

固体

熔点：

68.5ºC

沸点：

350.8ºC at 760 mmHg

闪点：

166ºC

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

AN7700000

CHEMICAL NAME :

2',6'-Acetoxylidide, 2-(diethylamino)-, hydrochloride, hydrate

CAS REGISTRY NUMBER :

6108-05-0

LAST UPDATED :

199706

DATA ITEMS CITED :

1

MOLECULAR FORMULA :

C14-H22-N2-O.Cl-H.H2-O

MOLECULAR WEIGHT :

288.86

WISWESSER LINE NOTATION :

2N2&1VMR B1 F1 &GH &QH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

292 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 179,580,1971

MSDS

Section 1. Chemical Product and Company Identification
Lidocaine Hydrochloride monohydrate
Common Name/
Trade Name
Lidocaine Hydrochloride monohydrate
Section 4. First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation
develops. Cold water may be used.
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical attention.
Serious InhalationNot available.
IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen
tight clothing such as a collar, tie, belt or waistband.
Serious IngestionNot available.
Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash PointsNot available.
Flammable LimitsNot available.
Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds.
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available.
Fire Fighting MediaSMALL FIRE: Use DRY chemical powder.
and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks onAs with most organic solids, fire is possible at elevated temperatures
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential
Hazardsdust explosion hazard.
Section 6. Accidental Release Measures
Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading
water on the contaminated surface and allow to evacuate through the sanitary system.
Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
Precautions
ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately
and show the container or the label. Keep away from incompatibles such as oxidizing agents.
StorageKeep container tightly closed. Keep container in a cool, well-ventilated area.
Lidocaine Hydrochloride monohydrate
Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep
exposure to airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be
a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product.
Exposure LimitsNot available.
Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (crystalline powder.)OdorOdorless.
TasteNot available.
Molecular Weight288.81 g/mole
ColorWhite.
pH (1% soln/water)Not available.
Not available.
Boiling Point
Melting Point74°C (165.2°F)
Critical TemperatureNot available.
Specific GravityNot available.
Vapor PressureNot applicable.
Vapor DensityNot available.
VolatilityNot available.
Not available.
Odor Threshold
Water/Oil Dist. Coeff.Not available.
Ionicity (in Water)Not available.
Dispersion PropertiesSee solubility in water.
SolubilityEasily soluble in cold water.
Insoluble in diethyl ether.
Soluble in benzene, ethanol, chloroform
Section 10. Stability and Reactivity Data
The product is stable.
Stability
Instability TemperatureNot available.
Excess heat, incompatible materials
Conditions of Instability
Incompatibility with variousReactive with oxidizing agents.
substances
CorrosivityNon-corrosive in presence of glass.
Special Remarks onNot available.
Reactivity
Special Remarks onNot available.
Corrosivity
PolymerizationWill not occur.
Lidocaine Hydrochloride monohydrate
Section 11. Toxicological Information
Routes of EntryAbsorbed through skin. Inhalation. Ingestion.
Toxicity to AnimalsAcute oral toxicity (LD50): 292 mg/kg [Mouse].
Chronic Effects on HumansCauses damage to the following organs: the nervous system.
May cause damage to the following organs: cardiovascular system, central nervous system (CNS).
Other Toxic Effects onHazardous in case of ingestion.
HumansSlightly hazardous in case of skin contact (irritant), of inhalation.
Special Remarks onNot available.
Toxicity to Animals
Special Remarks on
May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data
Chronic Effects on Humans
Special Remarks on otherAute Potential Health Effects:
Toxic Effects on HumansSkin: May cause skin irritation and numbness (anesthetic effect). When applied to the skin, it produces an
anesthetic effect by blocking the signals at the nerve endings of the skin. when compounded with an ointment
and applied topically, It may be absorbed by the skin cause systemic effects similar to that of ingestion.
Eyes: May cause eye irritation and numbness.
Inhalation: Dust may cause respiratory tract irritation and numbness.
Ingestion: Harmful of swallowed. May cause abdominal discomfort, nausea, vomiting. May affect
behavior/central nervous system (convulsions/seizures, drowsiness, lightheadedness, dizziness, confusion,
disorientation, muscle twitching or trembling, somnolence, unusual excitement, unusual tiredness or
weakness, nervousness, restlessness), cardiovascular system (hypotension, change in heart rate with
possibe cardiac arrest). May also cause shortness of breath or trouble breathing, ringing or buzzing in the
ears, feeling hot, cold or numb, increased sweating, blurred or double vision.
Chronic Potential Health Effects:
Skin: May cause allergic skin reaction with rash, hives, swelling, or abnormal sensation at the site of
application.
Ingestion/Inhalation: It is rare, but it may cause allergic reaction with cough, difficulty swallowing or tongue
swelling, dizziness or fainting, hives or swelling of the eyelids, face or lips; itching or skin rash, stuffy nose,
chest tightness, shortness of breath, trouble breathing or wheezing.
Medical Conditions Aggravated by Exposure: Hypersensitivity to material; respiratory depression; existing
cardiac conditions; broken or inflammed skin, burns, or open wounds at the place of application. More can be
absorbed into the body quickly, which increases the chance of side effects; Liver disease (severe). The risk
of side effects may be increased because of the slower removal of lidocaine from the body.
Section 12. Ecological Information
EcotoxicityNot available.
BOD5 and CODNot available.
Possibly hazardous short term degradation products are not likely. However, long term degradation products
Products of Biodegradation
may arise.
Toxicity of the ProductsThe products of degradation are more toxic.
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation
Section 13. Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental
Waste Disposal
control regulations.
Lidocaine Hydrochloride monohydrate
Section 14. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
No products were found. It is not listed on the TSCA inventory because it is a hydrate.
Federal and State
Regulations
California prop. 65: This product contains the following ingredients for which the State of California has
California
found to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has
found to cause birth defects which would require a warning under the statute: No products were found.
Other RegulationsOSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances.
Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance List
(NDSL).
China: Not listed on National Inventory.
Japan: Not listed on National Inventory (ENCS).
Korea: Not listed on National Inventory (KECI).
Philippines: Not listed on National Inventory (PICCS).
Australia: Not listed on AICS.
WHMIS (Canada) Not available under WHMIS (Canada).
Other Classifications
DSCL (EEC)R22- Harmful if swallowed.S36- Wear suitable protective clothing.
S46- If swallowed, seek medical advice
immediately and show this container or label.
Health Hazard
HMIS (U.S.A.)2 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
2 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
Lidocaine Hydrochloride monohydrate
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
SECTION 16 - ADDITIONAL INFORMATION
N/A

海关数据

中国海关编码：2924299090

概述：

2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

申报要素：

品名, 成分含量, 用途, 包装

摘要/Summary：

2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%