b-D-Allofuranuronic acid,5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-
- 中文别名：多抗霉素
- 中文释义：多抗霉素;保利霉素;多效霉素;多氧霉素;肽嘧啶核苷;宝丽安;多氧霉素B;多克菌
- 英文别名：POLYOXIN B;
piomycin;
Polyoxin AL;
POLYXIN
- CAS No.：19396-06-6
- 分子式：C17H25N5O13
- 分子量：507.41
- 精确分子量：507.14500
- PSA：309.98000
- InChI：InChI=1/C17H25N5O13/c18-6(8(25)5(24)3-34-16(19)32)13(29)20-7(15(30)31)11-9(26)10(27)14(35-11)22-1-4(2-23)12(28)21-17(22)33/h1,5-11,14,23-27H,2-3,18H2,(H2,19,32)(H,20,29)(H,30,31)(H,21,28,33)
- 分子结构式：
物化性质
- 密度：
- 1.774 g/cm3
- 折射率：
- 1.669
- 稳定性相关：
原药为浅褐色粉末。易溶于水，不溶于有机溶剂。对紫外线稳定，在酸性和中性溶液中稳定，但在碱性溶液中不稳定。
安全信息
- 密度：
- 1.774 g/cm3
- 折射率：
- 1.669
- 稳定性相关：
原药为浅褐色粉末。易溶于水，不溶于有机溶剂。对紫外线稳定，在酸性和中性溶液中稳定，但在碱性溶液中不稳定。
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BA2927000
- CHEMICAL NAME :
- Allofuranuronic acid, 5-(2-amino-2-deoxy-L-xylonamido)-1,5-dideoxy-1-(3,4-d ihydro-5- (hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl)-, monocarbamate (ester), beta-D-
- CAS REGISTRY NUMBER :
- 19396-06-6
- LAST UPDATED :
- 199204
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C17-H25-N5-O13
- MOLECULAR WEIGHT :
- 507.47
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14665 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C244,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >20 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,696,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15638 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C244,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (40),32,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,245,1981
分子结构与计算化学数据
分子结构数据
1、 摩尔折射率：106.73
2、 摩尔体积（cm3/mol）：285.9
3、 等张比容（90.2K）：930.5
4、 表面张力（dyne/cm）：112.1
5、 极化率（10-24cm3）：42.31
