trimetrexate glucuronate

物化性质

密度：

1.305 g/cm3

沸点：

647ºC at 760 mmHg

闪点：

345.1ºC

安全信息

密度：

1.305 g/cm3

沸点：

647ºC at 760 mmHg

闪点：

345.1ºC

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

LZ8945000

CAS REGISTRY NUMBER :

82952-64-5

LAST UPDATED :

199412

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C19-H23-N5-O3.C6-H10-O7

MOLECULAR WEIGHT :

563.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human

DOSE/DURATION :

2027 ug/kg

TOXIC EFFECTS :

Vascular - BP lowering not characterized in autonomic section Gastrointestinal - other changes Blood - thrombocytopenia

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human

DOSE/DURATION :

4054 mg/kg/3W-I

TOXIC EFFECTS :

Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

60 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

50 mg/kg/5D-C

TOXIC EFFECTS :

Blood - changes in leukocyte (WBC) count Blood - changes in platelet count Related to Chronic Data - changes in testicular weight

MUTATION DATA

TYPE OF TEST :

DNA damage

TEST SYSTEM :

Rodent - mouse Leukocyte

DOSE/DURATION :

500 nmol/L

REFERENCE :

BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 40,1981,1990