2-Oxazolidinone,5-[(2-methoxyphenoxy)methyl]-
- 中文别名：美芬诺酮; 5-[(2-甲氧基苯氧基)甲基]-2-恶唑烷酮
- 中文释义：美芬诺酮;5-[(2-甲氧基苯氧基)甲基]-2-恶唑烷酮
- 英文别名：5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one;
5-[(2-methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
- CAS No.：70-07-5
- 分子式：C11H13NO4
- 分子量：223.22
- 精确分子量：223.08400
- PSA：56.79000
- InChI：The Key: ZMNSRFNUONFLSP-UHFFFAOYSA-N
- 分子结构式：
物化性质
- 密度：
- 1.201g/cm3
- 沸点：
- 440ºC at 760 mmHg
- 闪点：
- 219.9ºC
- 折射率：
- 1.52
安全信息
- 密度：
- 1.201g/cm3
- 沸点：
- 440ºC at 760 mmHg
- 闪点：
- 219.9ºC
- 折射率：
- 1.52
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RQ3500000
- CHEMICAL NAME :
- 2-Oxazolidinone, 5-((o-methoxyphenoxy)methyl)-
- CAS REGISTRY NUMBER :
- 70-07-5
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C11-H13-N-O4
- MOLECULAR WEIGHT :
- 223.25
- WISWESSER LINE NOTATION :
- T5MVOTJ D1OR BO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3820 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,642,1964
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,198,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 11,212,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RAMAAB Revista de la Asociacion Medica Argentina. (Buenos Aires, Argentina) V.1-89, 1915-76. Discontinued. Volume(issue)/page/year: 74,82,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30330 mg/kg/30D-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in ovarian weight
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 18 gm/kg/30D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Liver - other changes Blood - normocytic anemia
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 87 gm/kg/26W-I
- TOXIC EFFECTS :
- Behavioral - ataxia Blood - normocytic anemia
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962
海关数据
中国海关编码：2934999090
- 概述：
- 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途
- 摘要/Summary：
- 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
分子结构与计算化学数据
分子结构数据
1、 摩尔折射率：71.47
2、 摩尔体积（cm3/mol）：202.7
3、 等张比容（90.2K）：648.4
4、 表面张力（dyne/cm）：104.5
5、 极化率（10-24cm3）：28.33
