2-Piperidinecarboxamide,1-butyl-N-(2,6-dimethylphenyl)-, (2S)-
- 中文别名：左布比卡因
- 中文释义：左布比卡因;1-丁基-N-(2,6-二甲基苯基)-哌啶-2-甲酰胺;LEVOBUPIVACAINE 左布比卡因;左旋布比卡因
- 英文别名：levobupivacaine;
(2S)-1-Butyl-N-(2,6-diMethylphenyl)-2-piperidinecarboxaMide;
1-Butyl-N-(2,6-dimethylphenyl)-piperidine-2-carboxamide;
2',6'-Pipecoloxylidide,1-butyl-,L-(-);
1-butyl-piperidine-2-carboxylic acid-(2,6-dimethyl-anilide)
- CAS No.：27262-47-1
- 分子式：
C18H28N2O
- 分子量：288.43
- 精确分子量：324.19700
- PSA：32.34000
- InChI：InChI=1/C9H19N.C7H7NO.C2H6.ClH/c1-2-3-7-10-8-5-4-6-9-10;9-6-8-7-4-2-1-3-5-7;1-2;/h2-9H2,1H3;1-6H,(H,8,9);1-2H3;1H
- 分子结构式：
物化性质
- 密度：
- 1.032 g/cm3
- 熔点：
- 254ºC (dec.)(lit.)
- 沸点：
- 423.4ºC at 760 mmHg
- 闪点：
- 209.9ºC
- 存储条件/存储方法：
- 库房通风低温干燥,与食品原料类分开存放
安全信息
- 密度：
- 1.032 g/cm3
- 熔点：
- 254ºC (dec.)(lit.)
- 沸点：
- 423.4ºC at 760 mmHg
- 闪点：
- 209.9ºC
- 存储条件/存储方法：
- 库房通风低温干燥,与食品原料类分开存放
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TK6090000
- CHEMICAL NAME :
- 2',6'-Pipecoloxylidide, 1-butyl-, L-(-)-
- CAS REGISTRY NUMBER :
- 27262-47-1
- LAST UPDATED :
- 199112
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C18-H28-N2-O
- MOLECULAR WEIGHT :
- 288.48
- WISWESSER LINE NOTATION :
- T6NTJ A4 BVMR B1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 52 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,273,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,273,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,273,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,273,1972
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 9700 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 31,273,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,78,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intratracheal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 14 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,78,1976
海关数据
中国海关编码：2933399090
- 概述：
- 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
