1-9-Luteinizinghormone-releasing factor (swine), 6-[O-(1,1-dimethylethyl)-D-serine]-,2-(aminocarbonyl)hydrazide
- 中文别名：戈舍瑞林
- 中文释义：戈舍瑞林;高舍瑞林
- 英文别名：Goserelin;
5-oxoprolylhistidyl-N-[18,18-diamino-7-(tert-butoxymethyl)-13-({2-[(2-carbamoylhydrazinyl)carbonyl]pyrrolidin-1-yl}carbonyl)-4-(4-hydroxybenzyl)-1-(hydroxymethyl)-10-(2-methylpropyl)-2,5,8,11-tetraoxo-3,6,9,12,17-pentaazaoctadec-17-en-1-yl]tryptophanamide;
5-oxo-L-prolyl-L-histidyl-N-[(1S,4S,7R,10S,13S)-18,18-diamino-7-(tert-butoxymethyl)-13-({(2S)-2-[(2-carbamoylhydrazino)carbonyl]pyrrolidin-1-yl}carbonyl)-4-(4-hydroxybenzyl)-1-(hydroxymethyl)-10-(2-methylpropyl)-2,5,8,11-tetraoxo-3,6,9,12,17-pentaazaoctad;
戈舍瑞林;
4-amino-6-hydroxy-2-mercaptopyrimidine;
4-Amino-6-hydroxy-2-mercaptopyrimidine monohydrate;
Z-D-glutamic acid 1-benzyl ester;
N-Methyl-D-alanine hydrochloride;
UNII-65NK71K78P;
L-lysyl-N-(2-benzoyl-4-chlorophenyl)-N-methylglycinamide;
Avizafone;
piperidyl-succinat);
dimethyl succinate polymer w/4-hydroxy-2,2,6,6-;
tetramethyl-1-piperidine ethanol;
Primesorb622;
Poly-(N-β-hydroxyethyl-2,2,6,6-tetramethyl-4-hydroxy-piperidyl)succinate;
TINUVIN 622;
Poly-(N--hydroxyethyl-2,2,6,6-tetramethyl-4-hydroxy-piperid
- CAS No.：65807-02-5
- 分子式：
C59H84N18O14
- 分子量：1269.42
- 精确分子量：1273.67000
- PSA：493.39000
- InChI：InChI=1/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25
- 分子结构式：
物化性质
- 外观与性状：
- 白色固体
- 密度：
- 1.5 g/cm3
- 折射率：
- 1.692
安全信息
- 外观与性状：
- 白色固体
- 密度：
- 1.5 g/cm3
- 折射率：
- 1.692
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OK6369800
- CHEMICAL NAME :
- Luteinizing hormone-releasing factor (pig), 6-(O-1,1-dimethylethyl)-D-serene)-10- deglycinamide-, 2-(aminocarbonyl)hydrazide
- CAS REGISTRY NUMBER :
- 65807-02-5
- LAST UPDATED :
- 199510
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C59-H84-N18-O14
- MOLECULAR WEIGHT :
- 1269.61
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 51 ug/kg
- TOXIC EFFECTS :
- Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Sense Organs and Special Senses (Eye) - diplopia Nutritional and Gross Metabolic - other changes
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 345,458,1995 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 12 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- REFERENCE :
- JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 10,478,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 12 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - other effects on male Endocrine - androgenic
- REFERENCE :
- JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 10,478,1989
