1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methyl-, (1R,5S)-
- 中文别名：N-甲基野靛碱; N-甲基金雀花碱
- 中文释义：N-甲基野靛碱;N-甲基金雀花碱
- 英文别名：N-Methylcytisine;
N－Methylcytisine;
Caulophylline
- CAS No.：486-86-2
- 分子式：
C12H16N2O
- 分子量：204.27
- 精确分子量：204.12600
- PSA：25.24000
- InChI：InChI=1/C12H16N2O/c1-13-6-9-5-10(8-13)11-3-2-4-12(15)14(11)7-9/h2-4,9-10H,5-8H2,1H3/t9-,10-/m0/s1
- 分子结构式：
物化性质
- 密度：
- 1.21g/cm3
- 熔点：
- 137-139ºC
- 沸点：
- 400.8ºC at 760mmHg
- 闪点：
- 191.9ºC
- 折射率：
- 1.616
- 蒸汽压：
- 1.24E-06mmHg at 25°C
安全信息
- 密度：
- 1.21g/cm3
- 熔点：
- 137-139ºC
- 沸点：
- 400.8ºC at 760mmHg
- 闪点：
- 191.9ºC
- 折射率：
- 1.616
- 蒸汽压：
- 1.24E-06mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HA4400000
- CHEMICAL NAME :
- Cytisine, 12-methyl-
- CAS REGISTRY NUMBER :
- 486-86-2
- BEILSTEIN REFERENCE NO. :
- 0012448
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C12-H16-N2-O
- MOLECULAR WEIGHT :
- 204.30
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 511 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity
- REFERENCE :
- BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 35,161,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 51 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity
- REFERENCE :
- BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 35,161,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 22 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,334,1943
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 7,24,1983
