b-D-Glucopyranosiduronic acid,(R)-cyanophenylmethyl
- 中文别名：维他命 B-17
- 中文释义：维他命 B-17
- 英文别名：β-?D-?Glucopyranosiduronic acid, (R)?-?cyanophenylmethyl;
b-D-Glucopyranosiduronic acid,(R)-cyanophenylmethyl
- CAS No.：1332-94-1
- 分子式：C14H15NO7
- 分子量：309.30
- 精确分子量：309.08500
- PSA：140.24000
- 分子结构式：
物化性质
- 密度：
- 1.55g/cm3
- 沸点：
- 581.1ºC at 760mmHg
- 闪点：
- 305.2ºC
- 折射率：
- 1.634
- 蒸汽压：
- 2.41E-14mmHg at 25°C
安全信息
- 密度：
- 1.55g/cm3
- 沸点：
- 581.1ºC at 760mmHg
- 闪点：
- 305.2ºC
- 折射率：
- 1.634
- 蒸汽压：
- 2.41E-14mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OD9910000
- CHEMICAL NAME :
- Laetrile
- CAS REGISTRY NUMBER :
- 1332-94-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C14-H15-N-O7
- MOLECULAR WEIGHT :
- 309.30
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea Liver - fatty liver degeneration
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 198 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 1286 mg/kg/24W
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Eye) - ptosis Behavioral - muscle weakness
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Multiple routes
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 4170 mg/kg/8W
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory stimulation
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 9600 pmol/plate
- REFERENCE :
- SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 198,625,1977
