1,3,5-Triazin-2(1H)-one,4-amino-1-b-D-arabinofuranosyl-
- 中文别名：法扎拉滨; 4-氨基-1-beta-D-阿拉伯呋喃糖基-1,3,5-三嗪-2(1H)-酮
- 中文释义：法扎拉滨;4-氨基-1-BETA-D-阿拉伯呋喃糖基-1,3,5-三嗪-2(1H)-酮
- 英文别名：1-.β.-D-Arabinofuranosyl-5-azacytosine;
5-azacytosine arabinoside;
5-azaaracytidine;
ara-AC;
4-Amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one;
Fazarabine
- CAS No.：65886-71-7
- 分子式：
C8H12N4O5
- 分子量：244.20
- 精确分子量：244.08100
- PSA：143.72000
- InChI：The Key: NMUSYJAQQFHJEW-ARQDHWQXSA-N
- 分子结构式：
物化性质
- 密度：
- 2.08g/cm3
- 熔点：
- 228-230ºC (decomposes)
- 沸点：
- 534.5ºC at 760mmHg
- 闪点：
- 277ºC
- 折射率：
- 1.823
安全信息
- 密度：
- 2.08g/cm3
- 熔点：
- 228-230ºC (decomposes)
- 沸点：
- 534.5ºC at 760mmHg
- 闪点：
- 277ºC
- 折射率：
- 1.823
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XZ2854400
- CHEMICAL NAME :
- s-Triazin-2(1H)-one, 4-amino-1-beta-D-arabinofuranosyl-
- CAS REGISTRY NUMBER :
- 65886-71-7
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C8-H12-N4-O5
- MOLECULAR WEIGHT :
- 244.24
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1557 ug/kg/72H-C
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Blood - agranulocytosis
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 2 umol/L
- REFERENCE :
- PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,297,1983
