2-Propanamine,1-(2,6-dimethylphenoxy)-
- 中文别名：美西律
- 中文释义：美西律;1-(2,6-二甲基苯氧基)-2-丙胺;2-溴-4\'-碘苯乙酮;1-Bromo-3-methoxy-2-methylbenzene;Propionanilide,2-amino-4\'-nitro-, monohydrochloride, L- (8CI);L-Alanine-4-nitroanilidehydrochloride;L-Alanine-p-nitroanilide hydrochloride;(S)-2-amino-N-(4-nitrophenyl)propionamide
- 英文别名：mexiletine;
Mexilitene;
Ritalmex;
Olzoron;
ko1173;
Cirumimeru;
MEXILITINE HCL;
1-(2,6-Dimethylphenoxy)-2-propanamine;
Toy;
Ko 1173Cl;
mexitil;
Katen
- CAS No.：31828-71-4
- 分子式：
C11H17NO
- 分子量：179.26
- 精确分子量：179.13100
- PSA：35.25000
- InChI：InChI:1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3
- 分子结构式：
物化性质
- 密度：
- 0.979 g/cm3
- 熔点：
- 203-205ºC
- 沸点：
- 271.5ºC at 760 mmHg
- 闪点：
- 112.2ºC
安全信息
- 密度：
- 0.979 g/cm3
- 熔点：
- 203-205ºC
- 沸点：
- 271.5ºC at 760 mmHg
- 闪点：
- 112.2ºC
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KR9300000
- CHEMICAL NAME :
- Ethylamine, 1-methyl-2-(2,6-xylyloxy)-
- CAS REGISTRY NUMBER :
- 31828-71-4
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C11-H17-N-O
- MOLECULAR WEIGHT :
- 179.29
- WISWESSER LINE NOTATION :
- ZY1&1OR B1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 63 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - nausea or vomiting
- REFERENCE :
- PMESAJ Postgraduate Medical Journal, Supplement. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1949- Volume(issue)/page/year: 53(Suppl 1),134,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 349 mg/kg/4D-I
- TOXIC EFFECTS :
- Blood - thrombocytopenia
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 100,162,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 41 mg/kg
- TOXIC EFFECTS :
- Toxic effects not yet reviewed
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5116974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 114 mg/kg
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 21,370,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 23 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 41,1130,1991
海关数据
中国海关编码：2922299090
- 概述：
- 2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
- 申报要素：
- 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
- 摘要/Summary：
- 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
