3-amino-1,2,4-benzotriazine-1,4-dioxide
- 中文别名：替拉扎明
- 中文释义：替拉扎明;3-氨基-1,2,4-苯并三嗪-1,4-二氧;替扎拉明
- 英文别名：tirapazamine;
4-hydroxy-1-oxido-1,2,4-benzotriazin-1-ium-3-imine;
3-Amino-1,2,4-benzotriazine 1,4-Dioxide;
3-Aminobenzo[e][1,2,4]triazine 1,4-dioxide;
4-Hydroxy-1-oxido-1,2,4-benzotriazin-1-ium-3-imine SR 259075 SR 4233 Tirazone Win 59075;
Tirapazamine
- CAS No.：27314-97-2
- 分子式：C7H6N4O2
- 分子量：178.14800
- 精确分子量：178.04900
- PSA：89.83000
- InChI：The Key: ORYDPOVDJJZGHQ-UHFFFAOYSA-N
- 分子结构式：
物化性质
- 外观与性状：
- 橙色-红色结晶粉末
- 密度：
- 1.68 g/cm3
- 熔点：
- 220ºC
- 沸点：
- 493.6ºC at 760 mmHg
- 闪点：
- 252.3ºC
- 折射率：
- 1.777
- 蒸汽压：
- 0mmHg at 25°C
安全信息
- 外观与性状：
- 橙色-红色结晶粉末
- 密度：
- 1.68 g/cm3
- 熔点：
- 220ºC
- 沸点：
- 493.6ºC at 760 mmHg
- 闪点：
- 252.3ºC
- 折射率：
- 1.777
- 蒸汽压：
- 0mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DM0671500
- CHEMICAL NAME :
- 1,2,4-Benzotriazine, 3-amino-, 1,4-dioxide
- CAS REGISTRY NUMBER :
- 27314-97-2
- BEILSTEIN REFERENCE NO. :
- 0179322
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C7-H6-N4-O2
- MOLECULAR WEIGHT :
- 178.17
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 59390 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >36 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine - other changes Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 89 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 101 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 19 mg/kg/2W-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Mammary gland
- DOSE/DURATION :
- 500 umol/L
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 11,1407,1990
