5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one,2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-,(2E,11R,11aS)-
- 中文别名：茅层霉素
- 中文释义：茅层霉素
- 英文别名：5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one,2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy-7,11-dimethoxy-,(2E,11R,11aS)-
- CAS No.：35050-55-6
- 分子式：C16H20N2O4
- 分子量：304.38
- 精确分子量：304.14200
- PSA：71.03000
- InChI：The Key: UQVNRKBFAXNOGA-SFVWDYPZSA-N
- 分子结构式：
物化性质
- 密度：
- 1.32g/cm3
- 沸点：
- 541.2ºC at 760 mmHg
- 闪点：
- 281.1ºC
- 折射率：
- 1.622
安全信息
- 密度：
- 1.32g/cm3
- 沸点：
- 541.2ºC at 760 mmHg
- 闪点：
- 281.1ºC
- 折射率：
- 1.622
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY8533000
- CHEMICAL NAME :
- 5H-Pyrrolo(2,1-c)(1,4)benzodiazepin-5-one, 2-ethylidene-1,2,3,10,11,11a-hexahydro-8-hydroxy- 7,11-dimethoxy-, (11R-(2E,11-alpha,11a-beta))-
- CAS REGISTRY NUMBER :
- 35050-55-6
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C16-H20-N2-O4
- MOLECULAR WEIGHT :
- 304.38
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3540 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Phage inhibition capacity
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 100 ng/plate
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,2819,1983
