2-Ethoxyethanol

物化性质

外观与性状：

透明无色,几乎无气味的液体

密度：

0.93 g/mL at 25 °C(lit.)

熔点：

-100 °C

沸点：

135 °C(lit.)

闪点：

107.6 °F

水溶解性：

miscible

折射率：

n20/D 1.407(lit.)

蒸汽压：

0.0227mmHg at 25°C

蒸汽密度：

3.1 (vs air)

存储条件/存储方法：

库房通风低温干燥,与氧化剂分开储运

稳定性相关：

1.稳定性^[23] 稳定

2.禁配物^[24] 强氧化剂、酸类、碱类

3.避免接触的条件^[25] 空气、光照

4.聚合危害^[26] 不聚合

其它信息：

1.性状：无色油状液体，有醚味。^[1]

2.熔点（℃）：-70^[2]

3.沸点（℃）：135.1^[3]

4.相对密度（水=1）：0.94（15℃）^[4]

5.相对蒸气密度（空气=1）：3.10^[5]

6.饱和蒸气压（kPa）：0.51（20℃）^[6]

7.临界压力（MPa）：4.24^[7]

8.辛醇/水分配系数：-0.32^[8]

9.闪点（℃）：43（CC）；49（OC）^[9]

10.引燃温度（℃）：235^[10]

11.爆炸上限（%）：15.6^[11]

12.爆炸下限（%）：1.7^[12]

13.溶解性：与水混溶，可混溶于乙醇、乙醚、丙酮等多数有机溶剂。^[13]

14.黏度（mPa·s,20ºC）：2.05

15.黏度（mPa·s,25ºC）：1.85

16.蒸发热（KJ/mol,b.p.）：40.56

17.蒸发热（KJ/mol,25ºC）：47.28

18.比热容（KJ/(kg·K),25ºC,定压）：2.32

19.电导率（S/m,20ºC）：9.3×10^-8

20.蒸气压（kPa,25ºC）：0.7

21.体膨胀系数（K^-1）：0.00097

22.溶度参数(J·cm^-3)^0.5：21.541

23.van der Waals面积（cm²·mol^-1）：8.230×10⁹

24.van der Waals体积（cm³·mol^-1）：56.100

25.液相标准热熔(J·mol^-1·K^-1) ：211.1

安全信息

外观与性状：

透明无色,几乎无气味的液体

密度：

0.93 g/mL at 25 °C(lit.)

熔点：

-100 °C

沸点：

135 °C(lit.)

闪点：

107.6 °F

水溶解性：

miscible

折射率：

n20/D 1.407(lit.)

蒸汽压：

0.0227mmHg at 25°C

蒸汽密度：

3.1 (vs air)

存储条件/存储方法：

库房通风低温干燥,与氧化剂分开储运

稳定性相关：

1.稳定性^[23] 稳定

2.禁配物^[24] 强氧化剂、酸类、碱类

3.避免接触的条件^[25] 空气、光照

4.聚合危害^[26] 不聚合

其它信息：

1.性状：无色油状液体，有醚味。^[1]

2.熔点（℃）：-70^[2]

3.沸点（℃）：135.1^[3]

4.相对密度（水=1）：0.94（15℃）^[4]

5.相对蒸气密度（空气=1）：3.10^[5]

6.饱和蒸气压（kPa）：0.51（20℃）^[6]

7.临界压力（MPa）：4.24^[7]

8.辛醇/水分配系数：-0.32^[8]

9.闪点（℃）：43（CC）；49（OC）^[9]

10.引燃温度（℃）：235^[10]

11.爆炸上限（%）：15.6^[11]

12.爆炸下限（%）：1.7^[12]

13.溶解性：与水混溶，可混溶于乙醇、乙醚、丙酮等多数有机溶剂。^[13]

14.黏度（mPa·s,20ºC）：2.05

15.黏度（mPa·s,25ºC）：1.85

16.蒸发热（KJ/mol,b.p.）：40.56

17.蒸发热（KJ/mol,25ºC）：47.28

18.比热容（KJ/(kg·K),25ºC,定压）：2.32

19.电导率（S/m,20ºC）：9.3×10^-8

20.蒸气压（kPa,25ºC）：0.7

21.体膨胀系数（K^-1）：0.00097

22.溶度参数(J·cm^-3)^0.5：21.541

23.van der Waals面积（cm²·mol^-1）：8.230×10⁹

24.van der Waals体积（cm³·mol^-1）：56.100

25.液相标准热熔(J·mol^-1·K^-1) ：211.1

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KK8050000

CHEMICAL NAME :

Ethanol, 2-ethoxy-

CAS REGISTRY NUMBER :

110-80-5

LAST UPDATED :

199712

DATA ITEMS CITED :

96

MOLECULAR FORMULA :

C4-H10-O2

MOLECULAR WEIGHT :

90.14

WISWESSER LINE NOTATION :

Q2O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Human

TYPE OF TEST :

Open irritation test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - guinea pig

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2125 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - withdrawal Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2000 ppm/7H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3900 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3400 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2400 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

7750 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2451 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1820 ppm/7H

TOXIC EFFECTS :

Behavioral - analgesia Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1707 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - chronic pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3900 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5799 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

1275 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

3300 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

900 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

1400 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

3000 ppm/24H

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

3070 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

26452 mg/kg/6W-I

TOXIC EFFECTS :

Behavioral - food intake (animal) Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

25 gm/kg/2W-I

TOXIC EFFECTS :

Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

18655 mg/kg/13W-C

TOXIC EFFECTS :

Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4000 ppm/4H/2W-I

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1370 mg/m3/7H/5W-I

TOXIC EFFECTS :

Blood - changes in spleen

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

25 gm/kg/2W-I

TOXIC EFFECTS :

Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

660 gm/kg/13W-C

TOXIC EFFECTS :

Endocrine - effect on menstrual cycle Endocrine - other changes Blood - changes in spleen

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

840 ppm/7H/12W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - other changes in urine composition Blood - microcytosis with or without anemia Blood - other changes

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

400 ppm/6H/13W-I

TOXIC EFFECTS :

Blood - normocytic anemia Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

500 mg/kg

SEX/DURATION :

male 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

7820 mg/kg

SEX/DURATION :

female 1-21 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

600 mg/kg

SEX/DURATION :

female 10-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1800 mg/kg

SEX/DURATION :

female 7-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

4500 mg/kg

SEX/DURATION :

male 6 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

10 ppm/6H

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

200 ppm/7H

SEX/DURATION :

female 1-19 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

600 ppm/7H

SEX/DURATION :

female 7-13 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

100 ppm/7H

SEX/DURATION :

female 14-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

DOSE :

50 gm/kg

SEX/DURATION :

female 7-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

DOSE :

50 gm/kg

SEX/DURATION :

female 7-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

DOSE :

50 gm/kg

SEX/DURATION :

female 7-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

1955 mg/kg

SEX/DURATION :

female 1-21 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

25 gm/kg

SEX/DURATION :

male 25 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

252 gm/kg

SEX/DURATION :

female 18 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

5600 mg/kg

SEX/DURATION :

female 8-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

12600 mg/kg

SEX/DURATION :

female 8-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

400 ppm/6H

SEX/DURATION :

male 65 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

160 ppm/7H

SEX/DURATION :

female 1-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

160 ppm/7H

SEX/DURATION :

female 1-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

160 ppm/7H

SEX/DURATION :

female 1-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

617 ppm/7H

SEX/DURATION :

female 1-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility

TYPE OF TEST :

Sperm Morphology

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Rodent - hamster Ovary

REFERENCE :

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-TWA 18 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 100 ppm (370 mg/m3) (skin) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,18,1973 OSHA PEL (Gen Indu):8H TWA 200 ppm (740 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 200 ppm (740 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 200 ppm (740 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 200 ppm (740 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (18 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (18.5 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 50 ppm (185 mg/m3);STEL 100 ppm (370 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 20 ppm (75 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 70 mg/m3;STEL 140 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (18 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 200 ppm (740 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 200 mg/m3 JAN 1993 OEL-RUSSIA:TWA 5 ppm;STEL 5 mg/m3 JAN 1993 OEL-SWEDEN:TWA 5 ppm (19 mg/m3);STEL 10 ppm (40 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (19 mg/m3);STEL 10 ppm (38 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 200 ppm (740 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (37 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHYLENEGLYCOL MONOETHYL ETHER-air:10H TWA 0.5 ppm (Sk)REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 31350 No. of Facilities: 43849 (estimated) No. of Industries: 253 No. of Occupations: 154 No. of Employees: 406097 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 31350 No. of Facilities: 16505 (estimated) No. of Industries: 153 No. of Occupations: 106 No. of Employees: 264436 (estimated) No. of Female Employees: 72493 (estimated)

毒理学数据：

1.急性毒性^[14]

LD50：2125mg/kg（大鼠经口）；3900mg/kg（大鼠经皮）；3300mg/kg（兔经皮）

LC50：2000ppm（大鼠吸入，7h）

2.刺激性^[15]

家兔经皮：500mg，轻度刺激（开放性刺激试验）。

家兔经眼：50mg，中度刺激。

3.亚急性与慢性毒性^[16] 大鼠暴露于1.49g/m³，每天7h，每周5d，5周，对血液细胞成分有轻微影响。兔经口，每天0.1ml/kg，第7d出现暂时性蛋白尿、血尿；1ml/kg，第8d因肾损害而死亡。

4.致突变性^[17]精子形态学：大鼠经口23400mg/kg，5周（间歇）。姐妹染色单体交换：仓鼠卵巢3170mg/L。

5.致畸性^[18] 大鼠孕后10~12d经口给予最低中毒剂量（TDLo）600mg/kg，致肌肉骨骼系统、心血管系统发育畸形。大鼠孕后7~16d皮肤染毒最低中毒剂量（TDLo）50g/kg，致中枢神经系统、泌尿生殖系统发育畸形。

6.其他^[19] 大鼠经口最低中毒剂量（TDLo）：600mg/kg（孕10~12d），致胚胎毒性（如胚胎发育迟缓），致骨骼肌肉发育异常，心血管（循环）系统发育异常。小鼠经口最低中毒剂量（TDLo）：25g/kg（25d，雄性），影响睾丸、附睾和输精管。

生态数据：

1.生态毒性^[20]

LC50：＞10000mg/L（96h）（蓝鳃太阳鱼）；＞5000mg/L（24h）（水蚤）

2.生物降解性^[21]

好氧生物降解性（h）：168~672

厌氧生物降解性（h）：672~2688

3.非生物降解性^[22]

空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为1d（理论）。

MSDS

第一部分：化学品名称

海关数据

中国海关编码：2909499000

概述：

2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%

申报要素：

品名, 成分含量, 用途

摘要/Summary：

2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

分子结构与计算化学数据

分子结构数据

1、摩尔折射率：23.86

2、摩尔体积（cm³/mol）：98.4

3、等张比容（90.2K）：227.6

4、表面张力（dyne/cm）：28.6

5、极化率（10^-24cm³）：9.45

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:1

3.氢键受体数量:2

4.可旋转化学键数量:3

5.互变异构体数量:无

6.拓扑分子极性表面积29.5

7.重原子数量:6

8.表面电荷:0

9.复杂度:21.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1