5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-8-(2-chloroacetyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)-
- 中文别名：14-氯柔红霉素
- 中文释义：14-Chloro Daunorubicin
- 英文别名：14-Chloro Daunorubicin;
14-chlorodaunorubicin;
14-ChlororuboMycin;
10-(4-amino-5-hydroxy-6-methyl-oxan-2-yl)oxy-8-(2-chloroacetyl)-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione;
14-ChlorodaunoMycin
- CAS No.：121250-06-4
- 分子式：C27H28ClNO10
- 分子量：0
- 精确分子量：561.14000
- PSA：185.84000
- InChI：The Key: YPCKPOWJKPVJRQ-TZSSRYMLSA-N
- 分子结构式：
物化性质
- 密度：
- 1.6g/cm3
- 沸点：
- 793.8ºC at 760mmHg
- 闪点：
- 433.9ºC
- 折射率：
- 1.695
- 蒸汽压：
- 1.43E-26mmHg at 25°C
安全信息
- 密度：
- 1.6g/cm3
- 沸点：
- 793.8ºC at 760mmHg
- 闪点：
- 433.9ºC
- 折射率：
- 1.695
- 蒸汽压：
- 1.43E-26mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QI9325500
- CHEMICAL NAME :
- 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-amino-2,3,6-trideoxy-alpha -L-lyxo- hexopyranosyl)oxy)-8-(chloroacetyl)-1-methoxy-6,8,11- trihydroxy-, (8S-cis)-
- CAS REGISTRY NUMBER :
- 121250-06-4
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C27-H28-Cl-N-O10
- MOLECULAR WEIGHT :
- 562.01
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 33500 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(2),24,1990
