5,12-Naphthacenedione,9-acetyl-9-amino-7-[(2-deoxy-b-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-,hydrochloride, (7S,9S)- (9CI)
- 中文别名：氨柔比星盐酸盐
- 英文别名：(1S,3S)-3-Acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-h exahydro-1-tetracenyl 2-deoxy-β-D-erythro-pentopyranoside hydroch loride (1:1);
Amrubicin (hydrochloride)
- CAS No.：110311-30-3
- 分子式：C25H25NO9.ClH
- 分子量：519.9282
- 精确分子量：519.13000
- PSA：176.61000
- 分子结构式：
物化性质
- 沸点：
- 717.8ºC at 760 mmHg
- 闪点：
- 387.9ºC
- 蒸汽压：
- 1.26E-21mmHg at 25°C
安全信息
- 沸点：
- 717.8ºC at 760 mmHg
- 闪点：
- 387.9ºC
- 蒸汽压：
- 1.26E-21mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QI9297160
- CHEMICAL NAME :
- 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-9-acetyl-9-amino-7-((2-deoxy-beta -D-erythro- pentopyranosyl)oxy)-6,11-dihydroxy-, hydrochloride, (7S-cis)-
- CAS REGISTRY NUMBER :
- 110311-30-3
- LAST UPDATED :
- 199609
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C25-H25-N-O9.Cl-H
- MOLECULAR WEIGHT :
- 519.97
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 80,77,1989
