5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-
- 中文别名：(1S,3S)-3-羟基乙酰基-3,5,12-三羟基-10-甲氧基-6,11-二氧代-1,2,3,4,6,11-六氢-1-并四苯基3-(3-氰基-4-吗啉基)-2,3,6-三脱氧吡喃己糖苷
- 中文释义：3\'-deamino-3\'-(3-cyanomorpholin-4-yl)doxorubicin
- 英文别名：3'-deamino-3'-(3-cyanomorpholin-4-yl)doxorubicin;
5,12-Naphthacenedione, 10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-.α.- L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11- trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-;
MRA-CN;
3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin;
cyanomorpholino-doxorubicin;
3'-Deamino-3'-(3-cyano-4-morpholinyl)adriamycin
- CAS No.：88254-07-3
- 分子式：C32H34N2O12
- 分子量：638.68
- 精确分子量：638.21100
- PSA：216.31000
- InChI：The Key: YIMDLWDNDGKDTJ-QLKYHASDSA-N
- 分子结构式：
物化性质
- 密度：
- 1.59g/cm3
- 沸点：
- 899.2ºC at 760 mmHg
- 闪点：
- 497.6ºC
- 折射率：
- 1.697
安全信息
- 密度：
- 1.59g/cm3
- 沸点：
- 899.2ºC at 760 mmHg
- 闪点：
- 497.6ºC
- 折射率：
- 1.697
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QI9405000
- CHEMICAL NAME :
- 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-(3-cyanomorpholino)-2,3,6- trideoxy- alpha-L-lyxo-hexopyranosyl)oxy)-8-(hydroxyacetyl)-1-m ethoxy-6,8,11-trihydr oxy-, (8s-cis)-
- CAS REGISTRY NUMBER :
- 88254-07-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C32-H34-N2-O12
- MOLECULAR WEIGHT :
- 638.68
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 30 ng/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,5599,1984
