8-Isoquinolinamine,1,2,3,4-tetrahydro-2-methyl-4-phenyl-
- 中文别名：诺米芬辛
- 中文释义：诺米芬辛;苯异喹胺;2-甲基-4-苯基-8-氨基-1,2,3,4-四氢异喹啉
- 英文别名：nomifensine;
2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine;
Nomifenison;
1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolin;
8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline;
linamiphen;
Nomifensine Maleate;
8-Isoquinolinamine,1,2,3,4-tetrahydro-2-methyl-4-phenyl;
8-amino-4-phenyl-2-methyl-1,2,3,4-tetrahydro-isoquinoline;
Nomifensine;
8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline;
Nomifensin;
1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin;
1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine
- CAS No.：24526-64-5
- 分子式：C16H18N2
- 分子量：238.32800
- 精确分子量：238.14700
- PSA：29.26000
- InChI：The Key: XXPANQJNYNUNES-UHFFFAOYSA-N
- 分子结构式：
物化性质
- 密度：
- 1.114g/cm3
- 沸点：
- 378.4ºC at 760mmHg
- 闪点：
- 164ºC
- 折射率：
- 1.622
- 蒸汽压：
- 6.28E-06mmHg at 25°C
安全信息
- 密度：
- 1.114g/cm3
- 沸点：
- 378.4ºC at 760mmHg
- 闪点：
- 164ºC
- 折射率：
- 1.622
- 蒸汽压：
- 6.28E-06mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NX4912700
- CHEMICAL NAME :
- Isoquinoline, 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-
- CAS REGISTRY NUMBER :
- 24526-64-5
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C16-H18-N2
- MOLECULAR WEIGHT :
- 238.36
- WISWESSER LINE NOTATION :
- T66 CNT&J C1 ER& JZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 7 mg/kg/7D-I
- TOXIC EFFECTS :
- Blood - hemorrhage Blood - thrombocytopenia
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,830,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 500 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 6,247,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 260 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - aggression
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,873,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 128 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 17,37,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 264 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 18,1,1979 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 4 mg/kg
- SEX/DURATION :
- lactating female 1 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
- REFERENCE :
- GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year: 23,103,1987
海关数据
中国海关编码：2933499090
- 概述：
- 2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
