1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylicacid, 7-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-,(8S)-
- 中文别名：螺普利
- 中文释义：螺普利;斯匹诺利;(8S-(7(R*(R*)),8R*))-7-(2-((1-(乙氧羰基)-3-苯基丙基)氨基)-1-氧代丙基)-1,4-二硫杂-7-氮杂螺[4.4]壬烷-8-羧酸;[8S-[7[R^^(R^^)],8R^^]]-7-[2-[[I-(乙氧羰基)-3-苯基丙基]氨基]-1-氧丙基]-1,4-二硫-7-氮杂螺[4.4]壬-8-羧酸
- 英文别名：(8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid;
Renormax;
Spirapril [INN:BAN];
Espirapril [Spanish];
Setrilan;
Spirapril (INN);
Not established;
Spiraprilum [Latin];
Sandopril;
Spirapril
- CAS No.：83647-97-6
- 分子式：
C22H30N2O5S2
- 分子量：466.61
- 精确分子量：466.16000
- PSA：146.54000
- InChI：The Key: HRWCVUIFMSZDJS-SZMVWBNQSA-N
- 分子结构式：
物化性质
- 密度：
- 1.32 g/cm3
- 沸点：
- 697.8ºC at 760 mmHg
- 闪点：
- 375.8ºC
- 折射率：
- 1.621
安全信息
- 密度：
- 1.32 g/cm3
- 沸点：
- 697.8ºC at 760 mmHg
- 闪点：
- 375.8ºC
- 折射率：
- 1.621
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JO4925000
- CHEMICAL NAME :
- 1,4-Dithia-7-azaspiro(4,4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl) amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))-
- CAS REGISTRY NUMBER :
- 83647-97-6
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C22-H30-N2-O5-S2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 13500 mg/kg/90D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 5400 mg/kg/90D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985
分子结构与计算化学数据
分子结构数据
1、 摩尔折射率：123.88
2、 摩尔体积（cm3/mol）：351.9
3、 等张比容（90.2K）：988.2
4、 表面张力（dyne/cm）：62.1
5、 极化率（10-24cm3）：49.11
