5-Chloro-2-Methyl-4-Isothiazolin-3-One

物化性质

外观与性状：

透明至黄色液体

密度：

1.25 (14% aq.)

沸点：

200.2ºC at 760 mmHg

闪点：

74.9ºC

折射率：

n20/D 1.378

蒸汽压：

0.328mmHg at 25°C

存储条件/存储方法：

库房低温,通风,干燥

稳定性相关：

1.异噻唑啉酮是通过断开细菌和藻类蛋白质的键而起杀生作用的。异噻唑啉酮与微生物接触后，能迅速地不可逆地抑制其生长，从而导致微生物细胞的死亡，故对常见细菌、真菌、藻类等具有很强的抑制和杀灭作用。杀生效率高，降解性好，具有不产生残留、操作安全、配伍性好、稳定性强、使用成本低等特点。能与氯及大多数阴、阳离子及非离子表面活性剂相混溶。高剂量时，异噻唑啉酮对生物黏泥剥离有显著果。

其它信息：

1.性状：白色固体。

2.溶解性：能与氯及大多数阴、阳离子及非离子表面活性剂相混溶。

安全信息

外观与性状：

透明至黄色液体

密度：

1.25 (14% aq.)

沸点：

200.2ºC at 760 mmHg

闪点：

74.9ºC

折射率：

n20/D 1.378

蒸汽压：

0.328mmHg at 25°C

存储条件/存储方法：

库房低温,通风,干燥

稳定性相关：

1.异噻唑啉酮是通过断开细菌和藻类蛋白质的键而起杀生作用的。异噻唑啉酮与微生物接触后，能迅速地不可逆地抑制其生长，从而导致微生物细胞的死亡，故对常见细菌、真菌、藻类等具有很强的抑制和杀灭作用。杀生效率高，降解性好，具有不产生残留、操作安全、配伍性好、稳定性强、使用成本低等特点。能与氯及大多数阴、阳离子及非离子表面活性剂相混溶。高剂量时，异噻唑啉酮对生物黏泥剥离有显著果。

其它信息：

1.性状：白色固体。

2.溶解性：能与氯及大多数阴、阳离子及非离子表面活性剂相混溶。

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

NX8156850

CHEMICAL NAME :

4-Isothiazolin-3-one, 5-chloro-2-methyl-

CAS REGISTRY NUMBER :

26172-55-4

LAST UPDATED :

199710

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C4-H4-Cl-N-O-S

MOLECULAR WEIGHT :

149.60

WISWESSER LINE NOTATION :

T5SNVJ B1 EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

DOSE/DURATION :

200 ng/plate

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,129,1983 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3204 No. of Facilities: 2332 (estimated) No. of Industries: 24 No. of Occupations: 25 No. of Employees: 42106 (estimated) No. of Female Employees: 17003 (estimated)

毒理学数据：

异噻唑啉酮有腐蚀性、对皮肤和眼睛有刺激性，操作时应配备防护眼镜和胶手套，一旦接触皮肤、眼睛时，应立即用大量清水冲洗。

MSDS

Material Safety Data Sheet
Section1. Identification of the substance
Product Name:5-Chloro-2-methyl-4-isothiazolin-3-one, tech grade, ¿14% in water. CMI/MI ¿2.0
Synonyms:CMI
Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
Section3. Composition/information on ingredients.
Ingredient name:5-Chloro-2-methyl-4-isothiazolin-3-one, tech grade, ¿14% in water. CMI/MI ¿2.0
CAS number:26172-55-4
Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.
Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:
Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C4H4ClNOS
Molecular weight:149.6
Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, sulfur oxides.
Section11. Toxicological information
No data.
Section12. Ecological information
No data.
Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.
Section14. Transportation information
Non-harzardous for air and ground transportation.
Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.
SECTION 16 - ADDITIONAL INFORMATION
N/A

海关数据

中国海关编码：2934999090

概述：

2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素：

品名, 成分含量, 用途

摘要/Summary：

2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

分子结构与计算化学数据

分子结构数据

1、摩尔折射率：35.04

2、摩尔体积（cm³/mol）：98.7

3、等张比容（90.2K）：267.2

4、表面张力（dyne/cm）：53.6

5、极化率（10-24cm3）：13.89

计算化学数据

1.疏水参数计算参考值（XlogP）:0.9

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积45.6

7.重原子数量:8

8.表面电荷:0

9.复杂度:156

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1