4-acetaminophenol

物化性质

密度：

1,293 g/cm3

熔点：

168-172 °C(lit.)

水溶解性：

14 g/L (20 ºC)

存储条件/存储方法：

1.储存于阴凉、通风的库房。远离火种、热源。保持容器密封。应与氧化剂分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。

稳定性相关：

1.避免与氧化物接触。

2.有毒，具有刺激性，使用时应避免与眼睛及皮肤接触。

其它信息：

1. 性状：无色单斜方棱形式结晶。无臭。味苦。

2. 密度（g/mL,25/4℃）： 1.293

3. 相对蒸汽密度（g/mL,空气=1）：未确定

4. 熔点（ºC）：169-170

5. 沸点（ºC,常压）：未确定

6. 沸点（ºC,5.2kPa）：未确定

7. 折射率：未确定

8. 闪点（ºC）：未确定

9. 比旋光度（º）：未确定

10. 自燃点或引燃温度（ºC）：未确定

11. 蒸气压（kPa,25ºC）：未确定

12. 饱和蒸气压（kPa,60ºC）：未确定

13. 燃烧热（KJ/mol）：未确定

14. 临界温度（ºC）：未确定

15. 临界压力（KPa）：未确定

16. 油水（辛醇/水）分配系数的对数值：未确定

17. 爆炸上限（%,V/V）：未确定

18. 爆炸下限（%,V/V）：未确定

19.溶解性：溶于甲醇、乙醇、二氯乙烯、丙酮和乙酸乙酯，微溶于乙醚和热水，几乎不溶于冷水，不溶于石油醚、戊烷和苯。

安全信息

密度：

1,293 g/cm3

熔点：

168-172 °C(lit.)

水溶解性：

14 g/L (20 ºC)

存储条件/存储方法：

1.储存于阴凉、通风的库房。远离火种、热源。保持容器密封。应与氧化剂分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。

稳定性相关：

1.避免与氧化物接触。

2.有毒，具有刺激性，使用时应避免与眼睛及皮肤接触。

其它信息：

1. 性状：无色单斜方棱形式结晶。无臭。味苦。

2. 密度（g/mL,25/4℃）： 1.293

3. 相对蒸汽密度（g/mL,空气=1）：未确定

4. 熔点（ºC）：169-170

5. 沸点（ºC,常压）：未确定

6. 沸点（ºC,5.2kPa）：未确定

7. 折射率：未确定

8. 闪点（ºC）：未确定

9. 比旋光度（º）：未确定

10. 自燃点或引燃温度（ºC）：未确定

11. 蒸气压（kPa,25ºC）：未确定

12. 饱和蒸气压（kPa,60ºC）：未确定

13. 燃烧热（KJ/mol）：未确定

14. 临界温度（ºC）：未确定

15. 临界压力（KPa）：未确定

16. 油水（辛醇/水）分配系数的对数值：未确定

17. 爆炸上限（%,V/V）：未确定

18. 爆炸下限（%,V/V）：未确定

19.溶解性：溶于甲醇、乙醇、二氯乙烯、丙酮和乙酸乙酯，微溶于乙醚和热水，几乎不溶于冷水，不溶于石油醚、戊烷和苯。

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

AE4200000

CHEMICAL NAME :

Acetanilide, 4'-hydroxy-

CAS REGISTRY NUMBER :

103-90-2

BEILSTEIN REFERENCE NO. :

2208089

LAST UPDATED :

199806

DATA ITEMS CITED :

92

MOLECULAR FORMULA :

C8-H9-N-O2

MOLECULAR WEIGHT :

151.18

WISWESSER LINE NOTATION :

QR DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

591 mg/kg/2D-I

TOXIC EFFECTS :

Liver - liver function tests impaired Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - aplastic anemia

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

4962 ug/kg

TOXIC EFFECTS :

Gastrointestinal - changes in structure or function of endocrine pancreas Liver - liver function tests impaired Blood - other changes

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

714 mg/kg

TOXIC EFFECTS :

Liver - other changes

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - infant

DOSE/DURATION :

1440 mg/kg/6D

TOXIC EFFECTS :

Behavioral - irritability Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

143 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

360 mg/kg/2D

TOXIC EFFECTS :

Gastrointestinal - nausea or vomiting Liver - other changes Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

801 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic Gastrointestinal - nausea or vomiting Liver - other changes

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

714 mg/kg

TOXIC EFFECTS :

Cardiac - EKG changes not diagnostic of specified effects

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

357 mg/kg

TOXIC EFFECTS :

Behavioral - anorexia (human) Behavioral - coma Gastrointestinal - nausea or vomiting

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

260 mg/kg

TOXIC EFFECTS :

Behavioral - coma Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

490 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

143 mg/kg/24H-I

TOXIC EFFECTS :

Behavioral - anorexia (human) Liver - hepatitis (hepatocellular necrosis), zonal Liver - jaundice, other or unclassified

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

650 mg/kg

TOXIC EFFECTS :

Vascular - BP lowering not characterized in autonomic section Vascular - other changes Nutritional and Gross Metabolic - metabolic acidosis

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Cardiac - other changes Lungs, Thorax, or Respiration - acute pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

400 mg/kg

TOXIC EFFECTS :

Behavioral - coma Liver - liver function tests impaired Nutritional and Gross Metabolic - metabolic alkalosis

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1944 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1205 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - tremor

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

338 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

367 mg/kg

TOXIC EFFECTS :

Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

310 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Blood - changes in spleen Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

826 mg/kg

TOXIC EFFECTS :

Behavioral - analgesia

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

2620 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - tremor

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Amphibian - frog

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

512 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

891 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

105 gm/kg/35D-C

TOXIC EFFECTS :

Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

68 gm/kg/13W-C

TOXIC EFFECTS :

Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

6080 mg/kg/19D-I

TOXIC EFFECTS :

Gastrointestinal - other changes Liver - changes in liver weight Blood - changes in leukocyte (WBC) count

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1600 mg/kg/2D-I

TOXIC EFFECTS :

Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

136 gm/kg/13W-C

TOXIC EFFECTS :

Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

336 gm/kg/40W-C

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), diffuse Liver - other changes Liver - changes in liver weight

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

164 gm/kg/78W-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

135 gm/kg/77W-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Liver - hepatitis (hepatocellular necrosis), zonal Liver - tumors

TYPE OF TEST :

TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

270 gm/kg/77W-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Endocrine - other changes

TYPE OF TEST :

TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

329 gm/kg/78W-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

650 mg/kg

SEX/DURATION :

female 29 week(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - Apgar score (human only) Reproductive - Effects on Newborn - other neonatal measures or effects Reproductive - Effects on Newborn - other postnatal measures or effects

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

417 mg/kg

SEX/DURATION :

female 20 week(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - hepatobiliary system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1300 mg/kg

SEX/DURATION :

female 31-32 week(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Effects on Newborn - other neonatal measures or effects

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1500 mg/kg

SEX/DURATION :

female 8-19 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

12500 mg/kg

SEX/DURATION :

female 14 day(s) pre-mating female 1-11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1 gm/kg

SEX/DURATION :

female 3 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - other postnatal measures or effects

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

35 gm/kg

SEX/DURATION :

male 70 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

25 mg/kg

SEX/DURATION :

male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

600 mg/kg

SEX/DURATION :

male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2500 mg/kg

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2500 mg/kg

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2 gm/kg

SEX/DURATION :

female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

TYPE OF TEST :

Micronucleus test

TYPE OF TEST :

Cytogenetic analysis

TYPE OF TEST :

Sister chromatid exchange

TYPE OF TEST :

Unscheduled DNA synthesis

TYPE OF TEST :

Micronucleus test

TYPE OF TEST :

DNA damage

TYPE OF TEST :

Unscheduled DNA synthesis

TYPE OF TEST :

Cytogenetic analysis

TYPE OF TEST :

Cytogenetic analysis

TYPE OF TEST :

Sister chromatid exchange

TYPE OF TEST :

Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Rodent - hamster Lung

DOSE/DURATION :

1 mmol/L

REFERENCE :

MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,51,1988 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,307,1990 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,307,1990 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,307,1990 TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 TOXICOLOGY REVIEW AUHPAI Australian Journal of Hospital Pharmacy. (B.R. Miller, POB 125, Heidelberg, Vic., Australia) V.1- 1971- Volume(issue)/page/year: 3(3),100,1973 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 12,601,1978 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB282-666 TOXICOLOGY REVIEW OBGNAS Obstetrics and Gynecology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1953- Volume(issue)/page/year: 58,57S,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80396 No. of Facilities: 1829 (estimated) No. of Industries: 7 No. of Occupations: 14 No. of Employees: 9269 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80396 No. of Facilities: 1261 (estimated) No. of Industries: 7 No. of Occupations: 26 No. of Employees: 65107 (estimated) No. of Female Employees: 56260 (estimated)

毒理学数据：

半数致死量（大鼠，经口）338 mg/kg.

生态数据：

对水是极其危害的，对鱼类有毒性，切勿让产品进入水体。

MSDS

4'-羟基乙酰苯胺修改号码：6
模块1. 化学品
产品名称：4'-Hydroxyacetanilide
修改号码：6
模块2. 危险性概述
GHS分类
　物理性危害未分类
　健康危害
急性毒性（经口）第4级
生殖细胞敏感性第2级
特异性靶器官毒性肝脏, 消化道, 心脏, 肾脏, 中枢神经系统
- 单一接触 [第1级]
特异性靶器官毒性呼吸系统, 睾丸
- 单一接触 [第2级]
特异性靶器官毒性肝脏, 血液（系统）, 肾脏
- 单一接触 [第1级]
特异性靶器官毒性甲状腺
- 单一接触 [第2级]
　环境危害
急性水生毒性第2级
慢性水生毒性第2级
GHS标签元素
　图标或危害标志
　信号词危险
　危险描述吞咽有害。
怀疑会造成遗传缺陷
对器官引起损害： 肝脏 消化道 心脏 肾脏 中枢神经系统
可能对器官产生损害： 呼吸系统 睾丸
可能因延长或接触对器官产生损害： 肝脏 血液（系统） 肾
脏
可能因延长或接触对器官产生损害： 甲状腺
4'-羟基乙酰苯胺修改号码：6
模块2. 危险性概述
对水生生物有毒性
长期影响对水生生物有毒性
　防范说明
[预防]使用前获取特定手册。
处理前必须阅读并理解所有安全措施。
切勿吸入。
避免释放到环境中。
使用本产品时切勿吃东西，喝水或吸烟。
处理后要彻底清洗双手。
使用个人所需的防护用具。
[急救措施]食入：若感不适，呼叫解毒中心/医生。漱口。
如接触到或相关接触：求医/就诊。
收集溢出物。
[储存]存放处须加锁。
[废弃处置]根据当地政府规定把物品/容器交与工业废弃处理机构。
模块3. 成分/组成信息
单一物质/混和物单一物质
化学名(中文名)：4'-羟基乙酰苯胺
百分比：>98.0%(HPLC)(N)
CAS编码：103-90-2
俗名：4-Acetamidophenol , Acetaminophen , Paracetamol
分子式：C8H9NO2
模块4. 急救措施
吸入：将受害者移到新鲜空气处，保持呼吸通畅，休息。求医/就诊。
皮肤接触：立即去除/脱掉所有被污染的衣物。用大量肥皂和水轻轻洗。
求医/就诊。
眼睛接触：用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。
求医/就诊。
食入：求医/就诊。漱口。
危害迹象：腹痛, 腹泻, 嗜睡, 恶心, 意识丧失, 呕吐
紧急救助者的防护：救援者需要穿戴个人防护用品，比如橡胶手套和气密性护目镜。
医生注意事项：建议医学观察。
模块5. 消防措施
合适的灭火剂：干粉，泡沫，雾状水，二氧化碳
特殊危险性：小心，燃烧或高温下可能分解产生毒烟。
特定方法：从上风处灭火，根据周围环境选择合适的灭火方法。
非相关人员应该撤离至安全地方。
周围一旦着火：如果安全，移去可移动容器。
消防员的特殊防护用具：灭火时，一定要穿戴个人防护用品。
模块6. 泄漏应急处理
个人防护措施，防护用具，使用特殊的个人防护用品（针对有毒颗粒的P3过滤式空气呼吸器）。远离溢出物/泄露
紧急措施：处并处在上风处。
泄露区应该用安全带等圈起来，控制非相关人员进入。
环保措施：小心，切勿排入河流等。因为考虑对环境有负面影响。
4'-羟基乙酰苯胺修改号码：6
模块6. 泄漏应急处理
控制和清洗的方法和材料：清扫收集粉尘，封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的
法律法规处置。
模块7. 操作处置与储存
处理
技术措施：在通风良好处进行处理。穿戴合适的防护用具。防止粉尘扩散。处理后彻底清洗双手
和脸。
注意事项：如果可能，使用封闭系统。如果粉尘或浮质产生，使用局部排气。
操作处置注意事项：避免所有部位的接触！
贮存
储存条件：保持容器密闭。存放于凉爽、阴暗处。
存放处须加锁。
远离不相容的材料比如氧化剂存放。
包装材料：依据法律。
模块8. 接触控制和个体防护
工程控制：尽可能安装封闭体系或局部排风系统。同时安装淋浴器和洗眼器。
个人防护用品
　呼吸系统防护：防尘面具，自携式呼吸器（SCBA），供气呼吸器等。使用通过政府标准的呼吸器。依
据当地和政府法规。
　手部防护：防渗手套。
　眼睛防护：护目镜。如果情况需要，佩戴面具。
　皮肤和身体防护：防渗防护服。如果情况需要，穿戴防护靴。
模块9. 理化特性
固体
外形（20°C）：
外观：晶体-粉末
颜色：白色类白色
气味：无味
pH:5.5 - 6.5 (saturated soln.H2O)
熔点：
169°C
沸点/沸程无资料
闪点：无资料
爆炸特性
　爆炸下限：无资料
　爆炸上限：无资料
蒸气压：9.3x10-4Pa/25°C
密度：无资料
溶解度：
[水]微溶于(1.4g/100mL, 20°C)
[其他溶剂]
溶于：丙酮, 乙醇, 二甲基甲酰胺, 乙酸乙酯
微溶于：醚
不溶于：苯, 石油醚
log水分配系数 =0.49
模块10. 稳定性和反应性
化学稳定性：一般情况下稳定。
危险反应的可能性：未报道特殊反应性。
4'-羟基乙酰苯胺修改号码：6
模块10. 稳定性和反应性
须避免接触的物质氧化剂
危险的分解产物:一氧化碳, 二氧化碳, 氮氧化物 (NOx)
模块11. 毒理学信息
急性毒性：orl-rat LD50:1944 mg/kg
scu-mus LD50:310 mg/kg
ipr-rat LD50:1205 mg/kg
orl-hmn LDLo:143 mg/kg
对皮肤腐蚀或刺激：无资料
对眼睛严重损害或刺激：无资料
生殖细胞变异原性：cyt-hmn-lym 200 mg/L
cyt-hmn-orl 42860 ug/kg
dns-rat-orl 500 mg/kg
mmo-sat 100 ug/disc (+S9)
致癌性：orl-mus TDLo:135 g/kg/77W-C
orl-rat TDLo:164 g/kg/78W-C
IARC =3 （无法对人类的致癌性进行分类）。
NTP =无资料
生殖毒性：无资料
RTECS 号码:AE4200000
模块12. 生态学信息
生态毒性：
鱼类：96h LC50:>100 mg/L (Oryzias latipes)
甲壳类：48h EC50:3.5 mg/L (Daphnia magna)
藻类：72h EC50:150 mg/L (Selenastrum capricornutum)
残留性 / 降解性：无资料
潜在生物累积 （BCF):无资料
土壤中移动性
　log水分配系数：0.49
　土壤吸收系数 （Koc）：无资料
　亨利定律无资料
constant(PaM3/mol):
模块13. 废弃处置
如果可能，回收处理。请咨询当地管理部门。建议在可燃溶剂中溶解混合，在装有后燃和洗涤装置的化学焚烧炉中
焚烧。废弃处置时请遵守国家、地区和当地的所有法规。
模块14. 运输信息
联合国分类：第9类 杂类
UN编号：3077
正式运输名称：环境有害物质, 固体, 不另作详细说明
包装等级：III
海洋污染物:Y
模块15. 法规信息
《危险化学品安全管理条例》（2002年1月26日国务院发布，2011年2月16日修订）: 针对危险化学品的安全使用、
生产、储存、运输、装卸等方面均作了相应的规定。
4'-羟基乙酰苯胺修改号码：6
模块16 - 其他信息
N/A

分子结构与计算化学数据

分子结构数据

1、 摩尔折射率：42.40

2、 摩尔体积（cm³/mol）：120.9

3、 等张比容（90.2K）：326.0

4、 表面张力（dyne/cm）：52.8

5、 介电常数：

6、 偶极距（10^-24cm³）：

7、 极化率：16.81

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:2

3.氢键受体数量:2

4.可旋转化学键数量:1

5.互变异构体数量:6

6.拓扑分子极性表面积49.3

7.重原子数量:11

8.表面电荷:0

9.复杂度:139

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1